Research Specialist at the Eukaryotic Single Cell Genomics facility
Do you want to contribute to top quality medical research?
The Eukaryotic Single Cell Genomics facility (ESCG), is looking for a highly qualified Research Specialist.
ESCG is a core facility at Karolinska Institutet and a national facility at Science for Life Laboratory (SciLifeLab). Based at SciLifeLab in Stockholm, the focus of ESCG is on high throughput streamlined transcriptome and genome analysis of large numbers of individual eukaryotic cells.
As a Research Specialist in the role of Team Leader, you are responsible for daily planning of ongoing activities in the team to ensure that we can deliver high-quality data to our users with the best possible approach and tools. In the role of team leader, it is expected that you coach and motivate the group of 5 research engineers and research specialists to work towards ESCG’s set goals. The group’s tasks are primarily focused on the construction of RNA and DNA sequence libraries from single-cell suspensions using state-of-the-art technologies. We achieve these goals by continuously updating our operations in line with the latest breakthroughs in our field. The person we are looking for will ensure that we achieve the quality goals we set.
Our first priority and highest goal is to deliver high quality data to our users. We achieve this goal by ensuring that methods and sample flows are the best possible for the task. A further objective is to ensure that internally developed methods become publicly available to the larger research community. The position entails staff responsibilities. Documentation, communication and team spirit are important for us to achieve our goals, and we are therefore happy to see that the applicant fits these key words.
You must delegate and schedule the group’s activities and manage the day-to-day activities of ESCG’s operations. Furthermore, you should motivate and coach members of the group in research-related issues. You will need to communicate and discuss results with researchers and companies and conduct meetings together with team members.
Other tasks may include project coordination, user consultations, cost calculations, invoice preparations, development of laboratory protocols (SOPs), procurement, ordering, shipments, inventory, risk assessments.
In addition to your team leader responsibilities, you will also contribute to some extent to laboratory activities. You will handle delicate primary cell samples, fragile RNA and sensitive instruments on a daily basis.
Your lab responsibilities will include all aspects of running single-cell methods, RNA-isolation and sequencing library construction, microscopy, image analysis, quality control, trouble-shooting. Methods include Smart-seq3 protocol, Chromium system from 10x Genomics and custom protocols. Additionally, you will operate liquid handling robots, qPCR/PCR, and Bioanalyzer instruments. Your work may also include to implement new single-cell methods at the facility.
You are service-minded and enjoy learning new methods. You are thorough, flexible, diligent in your laboratory work and proficient in work documentation. The position requires being able to work independently as well as in collaboration with others. You are able to work with several projects in parallel. You will work in an international team with frequent interactions with customers, therefore clear and informative communication skills, general computing proficiency, and a good knowledge of English are essential. Strong interpersonal skills will be highly valued.
To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, the applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.
- Ph.D. in molecular biology, biomedical science, biotechnology or similar discipline
- Previous work with RNA and cells
- Good knowledge in molecular biology techniques
- Leadership skills
- Communication in Swedish and English
- Method development in the molecular biology field
- Previous work with single-cell techniques
- Experience with high-throughput sample preparation of RNA and/or DNA
- Experience with laboratory automation, especially operating and programming Tecan pipetting robots
- Experience with data handling, programming and bioinformatics
- Experience with a LIMS system
- Experience with invoicing using iLab
- Experience with communicating with users
- Experience with laboratory work following Good Laboratory Practice (GLP), including biosafety rules
After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.
What do we offer?
A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.
We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio.
Please submit your application by 14 January 2023
Submit your application through Karolinska Institutets recruitment system.