Postdoc in Biomicrofluidics -3D microtissue production for drug development
KTH , School of Engineering Sciences in Chemistry, Biotechnology and Health
KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. We are Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world. Our research and education covers a wide area including natural sciences and all branches of engineering, as well as architecture, industrial management, urban planning, history and philosophy.
School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH) is one of the five schools of KTH and a strong constellation for research and education in the broader areas of health, environment, energy and materials. The School of Engineering Sciences in Chemistry, Biotechnology and Health conducts research and education in areas that cover several global challenges. Among them are the need of sustainable energy, health and aging population, climate change, sustainable production and working life, food production and clean water.
Science for Life Laboratory (SciLifeLab, http://www.scilifelab.se/) is a national center for large-scale life science research with an advanced technological infrastructure. At SciLifeLab, multidisciplinary research is carried out based on DNA sequencing, gene expression analysis, proteomics, bioinformatics, biostatistics and system biology. The goal is to enable Swedish researchers to analyze genes, transcripts and proteins in different organisms in order to map molecular mechanisms related to health and the environment. Examples of thematic research areas that are currently being processed within SciLifeLab are clinical genomics/proteomics, cancer genome and the genomics of complex diseases as well as ecological and environmental genomics.
We are offering a postdoctoral position is based in the Biomicrofluidics team within the KTH Nanobiotechnology Group at Science for Life Laboratory (SciLifeLab). The group is focused on droplet microfluidics and automation for 3D microtissue models and high throughput screening. The project is conducted in collaboration with large pharmaceutical partner and academic precision medicine partners.
The aim of the project is to produce and characterize human 3D microtissue models at the scale needed for early drug development using a novel droplet microfluidics platform in combination with automated liquid handling and miniaturization tools. 3D microtissue models can more accurately recapitulate in vivo drug response than 2D tissue or single cells, but has not been deployable at the scale needed for high throughput screening. This project aims to develop the technologies to scale up the efficient production and handling of 3D microtissues for state-of-the-art high throughput screening workflows.
The successful candidate will perform work at the interface of tissue engineering, microfluidics and automation, including:
- development of droplet microfluidic devices for 3D microtissue assembly
- characterization and validation of human 3D microtissue
- automation of microfluidic tools with broad applicability
- development and application of analysis tools in e.g. image analysis
- support innovation and ideation for grant proposals
What we offer
- A position at a leading technical university that generates knowledge and skills for a sustainable future
- Engaged and ambitious colleagues along with a creative, international and dynamic working environment
- Works in Stockholm, in close proximity to nature
- An interdisciplinary and applied project in close collaboration with researchers from Karolinska Institutet and an international pharmaceutical company
- A doctoral degree or an equivalent foreign degree within a subject relevant to the position, e.g. Bioengineering, Biotechnology, Chemistry, Cell and molecular biology, Medical science, Electrical engineering, Mechanical engineering or Microfluidics, obtained within the last three years prior to the application deadline (With some exceptions for special reasons such as periods of sick or parental leave, kindly indicate if such reason exists in your resume).
- There are high requirements on outstanding research and publication record. Well-developed analytical and problem-solving skills are also required (research expertise).
- Good command of English orally and in writing is required to present and publish research results.
- The candidate should have a strong background in at least one of the areas; design and implementation applied microfluidics for the life sciences, research on mammalian cells/tissues and biotechnological instrumentation or adjoining research fields.
- Programming experience, particularly in Python or similar as well as experience with laboratory automation.
- Teaching abilities, e.g. from supervision or mentoring of students and awareness of diversity and equal treatment issues with a special focus on gender equality and sustainability.
We are looking for a strongly motivated and performance oriented person, who takes initiative and can work both independently and in collaboration with others. Well-developed analytical and problem solving skills are also required.
Great emphasis will be placed on personal competency
Trade union representatives
You will find contact information to trade union representatives at KTH’s webbpage.
Log into KTH’s recruitment system in order to apply to this position. You are the main responsible to ensure that your application is complete according to the ad.
Your complete application must be received at KTH no later than the last day of application, midnight CET/CEST (Central European Time/Central European Summer Time).
About the employment
The position offered is for, at the most, two years.
A position as a postdoctoral fellow is a time-limited qualified appointment focusing mainly on research, intended as a first career step after a dissertation.
|Type of employment||Temporary position longer than 6 months|
|Contract type||Full time|
|First day of employment||According to agreement|
|Number of positions||1|
|Contact||Håkan Jönsson, e-post: firstname.lastname@example.org|
|Last application date||05.Feb.2021 11:59 PM CET|