Research Assistant ADME

Uppsala University, Department of Pharmacy

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 54,000 students, more than 7,500 employees and a turnover of around SEK 8 billion.

Uppsala University Drug Optimization and Pharmaceutical Profiling Facility (UDOPP) is a local platform at the Department of Pharmacy, Uppsala University. UDOPP’s main task is to perform in silico and in vitro ADME profiling (Absorption, Distribution, Metabolism, Excretion) of active substances identified in screening programs in collaboration with Swedish academic research groups. UDOPP also offers services within bioanalysis and preclinical development of drug candidates. The facility was founded in 2010 and is currently affiliated with the Drug Development Platform at SciLifeLab (SciLifeLab DDD) and the Innovative Medicine Initiative (IMI), Conception. Further information is available on the following website: UDOPP

Prof. Thomas Helleday’s research group (Karolinska Institutet) and UDOPP have been awarded funding from the Swedish Research Council (VR) to develop “New medical therapy for virus-induced lung damage. Development of OGG1 inhibitors against inflammation and fibrosis of the lung associated with viral infection “.

Therefore, we are now recruiting a motivated and flexible ADME research assistant to expand our capacity. The position will be located at UDOPP, Department of Pharmacy, Biomedical Center (BMC), Uppsala University. More information about the department and the research groups can be found at Pharmacy

Duties
The candidate will perform experimental work focused on physico-chemical, in vitro ADME and cell-based methods for small molecule drug candidates (OGG1 inhibitors). The candidate is also expected to analyze in vitro samples using LC-MSMS and report results to the respective project team. The candidate will be part of the OGG1 project team.

Requirements
The successful candidate should have a master’s degree in biology, biochemistry, pharmacy or similar. The candidate should have 5 years of experience from the biotech/pharmaceutical industry and worked as a project member in preclinical drug development projects.

The right applicant has good laboratory skills, including the ability to design and perform experiments, analyze the data and report in vitro ADME results according to the regulatory agencies’ recommendations.

The ideal candidate is flexible, motivated, has good problem-solving ability and can deliver on short timelines. Good social skills, good co-operation skills and ability to present within interdisciplinary teams in English are required.