Research assistant (experimental/computational in genomics and transcriptomics)
Do you want to contribute to top quality medical research?
The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet in Stockholm conducts research and teaching in infection biology, immunology, cell biology and cancer. Our keywords are interdisciplinarity, clinically based basic research and national and international cooperation.
The research group of Dr Claudia Kutter seeks a research assistant (either experimental or computational) in the field of functional genomics and RNA biology. The Kutter lab has a track record in deciphering molecular mechanism by which RNAs (i.e. long noncoding, transfer and small RNA) regulate genes and genome structure in mammalian somatic tissue and in the germline (Geng et al. Genome Research 2022, Søndergaard et al. Gut, 2022, Gao et al. Genome Research 2022, Atanasoai et al. bioRxiv 2021). As a research assistant you will be part of a multidisciplinary and collaborative research team active within the fields of RNA and chromatin biology, functional genomics and regulative transcriptomics.
Your mission
As a member of the Kutter lab, you will apply and optimize novel transcriptomic approaches (based on bulk and single cell RNA profiling) to study gene regulation and RNA processing using mammalian systems (primary tissues and cell lines), carry out validation experiments involving biochemical and molecular biological tools, and participate in the general duties of the team. As a research assistant you will take a strong lead in the project design and management as well as data generation, analyses and interpretation, and collaborate with other team members. You are expected to report the scientific results by writing scientific papers, attending scientific meetings, and effectively communicate with peers. The ability to work in a highly interdisciplinary and international environment, and to engage in continuous professional development is a must.
The laboratory is located at SciLifeLab on the Karolinska Institute campus in Stockholm. SciLifeLab offers an attractive research environment, provides state-of-the-art instrumentation and core facilities, and is home to the second largest sequencing cluster in Europe. SciLifeLab is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology, and Stockholm University. It hosts research groups with diverse backgrounds and expertise, creating a unique interface between basic biology, genomics, bioengineering, drug discovery, and translational medicine.
Your profile
Applicants should have been awarded a degree in applied biosciences and/or bioinformatics and have received training in experimental or computational methods or both.
We are looking for an enthusiastic and highly motivated candidate who has a solid background in genomics, transcriptomics, molecular biology, genetics and/or biochemistry. Proven experience in working with eukaryotic gene regulation, transcriptome-wide studies and in RNA biology is essential. Prior knowledge in bioinformatics and R programming for statistical computing and graphics is advantageous.
The ideal candidate should be collaborative, scientifically adventurous, curiosity-driven, and should bring independent and original ideas into the project. Any previous records of independent research as well as productive interactions within a multi-disciplinary team environment (e.g., first- and/or co-author publications in high profile journals) are beneficial. Since you will work in a multidisciplinary environment you need the ability to work with other scientists.
Good communication skills in spoken and written English are important.
What do we offer?
A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.
Location: Solna, Science for Life Laboratory