Uppsala University, Department of Pharmacy
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 54,000 students, more than 7,500 employees and a turnover of around SEK 8 billion.
Project: 3D printing of personalized dosage forms for treatment of pediatric inflammatory bowel disease
The Department of Pharmacy offers an interdisciplinary environment at the center of the pharmaceutical arena. With frontline research, first-rate education and extensive collaborations we constitute an important driving force in the development of our academic field. In this inspiring environment our rich diversity of research groups, several of international prominence, develop and conduct work of great scientific importance. Among our core competences are in vitro ADME models, enabling formulations, advanced in vivo methods, computational modelling and simulations, as well as patient and societal aspects, from optimizing the use of drugs in individuals to societal pharmaceutical policies. Together, we form a unique cluster of academic competences within pharmaceutical science, playing a key role in shaping the future of pharmacy in both Sweden and globally.
Our scientific focus areas in selection: Molecular Pharmaceutics, Drug Delivery, Pharmaceutical nanotechnology, Pharmacokinetics, Pharmacodynamics, Pharmacometrics, Clinical Pharmacy, Pharmacoeconomics, Pharmacoepidemiology, Pharmacotherapy, Social Pharmacy.
SciLifeLab (www.scilifelab.se) is a Swedish national center for molecular biosciences with focus on health and environmental research. The center combines frontline technical expertise with advanced knowledge of translational medicine and molecular bioscience. SciLifeLab is hosted by four Swedish universities (Uppsala University, Karolinska Institutet, KTH Royal Institute of Technology and Stockholm University) and collaborates with several other universities.
The research group: The research assistant will be linked to the research group Molecular Pharmaceutics. The group takes a multidisciplinary approach and combines computational chemistry and bioinformatics with cell- and molecular biology, biopharmaceutics, pharmaceutics and physical chemistry to find new ways to predict and define rate-limiting barriers to the absorption and organ distribution of different types of drugs. We anticipate that our research will provide insights into new mechanisms for drug absorption, disposition and delivery, which will support development of new therapeutic strategies for efficient oral drug delivery. More information at Bergström. The position is placed in the research group of Alexandra Teleki Teleki group who is associated with SciLifeLab. The overall goal of the Teleki research group is to transform innovative nanomedical approaches to clinically relevant, patient-compliant diagnosis and treatment.
The project: The research assistant will work in the area 3D printed oral dosage forms of biological therapies for the treatment of pediatric inflammatory bowel disease (IBD). Moderate to severe cases of inflammation are treated in the clinic today with biological drug therapies via systemic administration. However, there is a need to develop more patient-compliant administration of these therapies with a local delivery of optimized drug doses to reduce systemic adverse effects. During treatment of pediatric IBD, drug dose needs to be easily changed in response to the disease state as well as the development of the child. This project will explore additive manufacturing technologies for personalized oral IBD therapies for children. The research assistant will work with powder-based and semi-solid extrusion printing approaches and vary tablet composition to explore various targeting and controlled release concepts to the colon. Detailed tablet characterization will be carried out and drug release in vitro will be studied.
Focus areas of the position: Oral drug delivery, Additive manufacturing, Colloidal capsules, Colonic drug delivery.
Qualifications: Applications from highly motivated candidates are welcome. The successful candidate should have a Bachelor or Master of Science in Pharmaceutics, Drug Discovery and Development, Chemical/biochemical engineering, Biomedicine or similarly relevant field, and have good communication skills in oral and written English. Previous experience of any of the core subjects are meritorious.
How to apply: The application, preferably written in English, is submitted through the application portal of Uppsala University and should contain.
About the employment
The employment is a temporary position, 12 months. Scope of employment 100%. Starting date 1 June or as agreed. Placement: Uppsala.
For further information about the position, please contact: Associate Professor Alexandra Teleki, tel 018-471 4745, e-post firstname.lastname@example.org.
Please submit your application by 16 May 2022, UFV-PA 2022/1496.