Staff scientist – Assay development and small molecule screening
Chemical Biology Consortium Sweden, CBCS, will from 2022 be a Swedish Research Council funded infrastructure of national interest. This means that the existing capabilities will be strengthened and new capabilities and four new nodes – at Lund, Uppsala, Linköping and Gothenburg Universities, respectively, will be established. CBCS (www.CBCS.se) has been in operation since 2010 with two nodes at KI and at Umeå University, respectively, and is an infrastructure for chemical biology at Science for Life Laboratory (www.scilifelab.se) in the Chemical Biology and Genome Engineering platform. CBCS offers services for the identification of chemical tools (bioactive small-molecules) for all fields of life sciences. The infrastructure offers collaborative service and guidance within assay development, small-molecule screening and hit to chemical probe optimization. Additional service offerings in small-molecule profiling, including Cell Painting, and screening in primary and complex disease models are currently being established.
The KI node is currently seeking a versatile biologist skilled in assay development and small molecule screening who will help CBCS in its mission of identifying, developing and optimizing high-quality small molecule tool compounds for academic researchers.
The activities will include establishing and performing primary assays in screening format with the aim to develop and optimize specific small molecule probe compounds or profile small molecules for efficacy across cell lines, and patient models. Activities will also include evaluating different assay formats, establishing cell-based and biochemical high throughput and high content screens, working with primary patient cells or complex disease models. You will be responsible for managing projects in close collaboration with researchers from diverse backgrounds and delivering high-quality data.
Eligible applicants will have a well-documented track record of relevance to the employment. Previous experience of both biochemical and cell-based assay development and small-molecule screening from pharmaceutical industry or academic screening centers is highly merited. You will need a strong passion for daily experimental work and an aptitude for analyzing, managing, interpreting and reporting high quality screening data. Laboratory automation experience and an ability to troubleshoot screening equipment, including robotic liquid handlers and plate readers will also be considered valuable. The successful candidate must have a staff scientist mind set, be service minded and dedicated to high quality and reproducible data production, have very good interpersonal and cooperation skills, enjoy collaborative science, be flexible and capable of working independently in a structured and efficient way. Excellent communication skills in written and spoken English are essential, as well as documentation skills and experience with electronic lab notebooks is merited.
What do we offer?
Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.
Welcome to apply at the latest 2022-01-16