Context crosstalk of macrophages in cardiovascular disease

September 29, 2022, 14:00 – 15:00


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Air&Fire, SciLifeLab Stockholm
Tomtebodavägen 23 A
Solna, Sweden
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Context crosstalk of macrophages in cardiovascular disease

September 29 @ 14:00 15:00 CEST

Erik A.L. Biessen, Maastricht University, the Netherlands

In this paper, Biessen et al. introduce a novel approach that integrates 15-plex multispectral immunofluorescent microscopy with mass spectrometry imaging to reveal murine atherosclerotic plaque myeloid heterogeneity. It maps the phenotypes’ tissue localization while allowing their further histological characterization and correlations with their cellular and molecular microenvironmental contexts.

Prof. Erik Biessen graduated in Biophysical Chemistry at Groningen University, Netherlands (1985). He joined the Division of Biopharmaceutics of Leiden University (Prof. Dr. Th.J.C. Van Berkel) as a post-doctoral fellow and was selected for the prestigious Netherlands Heart Foundation (NHF) funded Molecular Cardiology Program to become Established Investigator in 2001. Dr. Biessen received an innovational research incentive premium of N.W.O in 2001 (VIDI/VICI precursor), acquired a second Established Investigatorship of the NHF in 2004, and was appointed Professor in Therapeutic Gene Modulation at Leiden University in 2005. Since 2007 he is heading the Experimental Vascular Pathology group of CARIM (MUMC). Dr. Biessen has a part-time affiliation at the Institute for Molecular cardiovascular research of RWTH Aachen, Germany since 2015. Dr. Biessen is/has been a board member of NHS-CVON ( 2010- 2013), Dutch Atherosclerosis Society (>2008), ZonMW TOP grant committee, FWO Med6 Expert panel of FWO, and Ph.D. assessment board of IWT (both Belgium). He is a scientific adviser of VantageView (St Louis, USA), associate editor of Cardiovascular Research and Atherosclerosis, and participates in several European research programs (e.g. ERA-CVD-AtheroMacHete, 3 H2020 ITNs (Intricare, Evolution, CareSYAN), Interreg-EMR Healthy Ageing and EurLipids). Dr. Biessen aims for curiosity-driven cross-disciplinary research with an open eye for the valorization of findings. Through the years his focus has shifted from biophysical chemistry, via medicinal chemistry and drug targeting to pathomechanistic studies of cardiovascular diseases (>2001), with a main emphasis on inflammation.

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Last updated: 2022-09-13

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