CryoEM in Drug Discovery
June 8 @ 14:00 – June 9 @ 12:00 CEST
CryoEM has quickly become an essential tool in academic research, with more than 1200 cryoEM structures deposited in the PDB in 2019. CryoEM is now also showing a significant impact on drug discovery in industry and academia.
This symposium, co-arranged by the Drug Discovery and Development platform and the CryoEM unit at SciLifeLab, highlights some of the recent advances in the field and familiarises the audience with the requirements, opportunities, and limitations of the technique. Speakers include leading scientists from both major pharma companies and academia.
By attending this symposium, you learn what cryoEM can bring to your research, what resources are available to Swedish researchers, and how to get started. We welcome both Swedish and international participants.
Session 1
All time slots below are in UTC+2 / CEST Time zone [Stockholm, Sweden].
June 8th – Afternoon
| 14:00 | Welcome words Annika Jenmalm-Jensen, Infrastructure Director, SciLifeLab |
| 14:05 | Introduction to the cryo-EM Unit at SciLifelab Marta Carroni, SciLifeLab/Stockholm University, Sweden |
| 14:15 | From Concept to Reality: CryoEM as an Integral Part of Drug Discovery and Development Corey Strickland; Merck, Kenilworth, United States |
| 14:55 | CryoEM at AstraZeneca Chris Phillips; Astra Zeneca, UK |
| 15:25 | Short break |
| 15:30 | An integrated cryo-EM and AI based approach for new vaccine identification Ilaria Ferlenghi, GSK, UK |
| 16:00 | Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 1.68 Å resolution Hartmut Luecke, University of Oslo, Norway |
| 16:30 | CryoEM in industry, with an artisanal touch Alexis Rohou, Genentech, United States |
| 17:00 | Wrap up Marta Carroni, SciLifeLab/Stockholm University, Sweden |
Session 2
All time slots below are in UTC+2 / CEST Time zone [Stockholm, Sweden].
June 9th – Morning
| 09:00 | Session 2 Welcome Marta Carroni, SciLifeLab/Stockholm University, Sweden |
| 09:00 | Cryo-EM and crystal structure of the emerging cancer target PAICS in complex with a low-nanomolar inhibitor Jana Skerlova, Stockholm University, Sweden |
| 09:15 | Using Cryo-EM for GPCR Drug Discovery and Development Patrick M. Sexton, Monash University, Parkville, Australia |
| 09:55 | Short break |
| 10:00 | Cryo-EM at Novartis Maryam Khoshouei, Novartis, Switzerland |
| 10:30 | CryoEM of SARM1 reveals a trigger of axon degeneration Katie Cunnea, Evotec, UK |
| 11:00 | Concluding Remarks Marta Carroni, SciLifeLab/Stockholm University, Sweden Per Arvidsson, SciLifeLab/Karolinska Institutet, Sweden Anders Olsson, SciLifeLab/KTH Royal Institute of Technology, Sweden |
Scientific committee
- Marta Carroni, Head of Cryo-EM unit, SciLifeLab
- Per Arvidsson, Director Drug Discovery and Development platform, SciLifeLab
- Anders Olsson, Head of Protein Expression and Characterization unit, SciLifeLab
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