Cell and Molecular Biology – DDLS symposium
April 25, 2024 @ 11:30 – April 26, 2024 @ 17:00 CEST
Welcome to the Cell and Molecular Biology Symposium, starting with lunch at Restaurant Lyktan from 11:30. The conference then takes place in the Birgit Thilander Lecture Hall in Academicum. The program includes presentations from local and national experts within data driven life science research – and a keynote lecture by Prof. Edda Klipp from the Humboldt University in Berlin.
Day two, on April 26, takes place in the AstraZeneca facilities in Mölndal. Here we will meet with the exciting BioVenture Hub and learn about how AstraZeneca works with data driven life science in a clinical setting. Bus transfer from Clarion Hotel Post leaves at 07:30 directly to Astra Zeneca.
Practical information
Public Transport to Medicinareberget
Thursday, April 27
Please note that due to construction work, there are disturbances in the tram operations at nearby stops Medicinaregatan and Sahlgrenska Huvudentrén.
Find your best route through the Västtrafik website or app.
Coach to Astra Zeneca
Friday, April 26
A chartered bus will depart from Clarion Post Hotel at 07:30, directly to the Astra Zeneca Conference Center (PGN Entrance).
Guidelines for Self-Transport Arrivals to Astra Zeneca
Friday, April 26
Whether you’re arriving by public transport, bike, or car, kindly make your way to the KC-entrance at Pepparedsleden 1.
Please be punctual at 08:00, as you’ll be guided from the entrance to the conference area.
Program
Click to expand and see the program
Thursday, April 25
| April 25 | |
|---|---|
| 10:30 | Expert Group meeting |
| 11:30 | Lunch Restaurant Lyktan |
| 13:00 | Welcome Words Margit Mahlapuu, University of Gothenburg Sverker Holmgren, Chalmers Ola Engkvist, AstraZeneca |
| 13:10 | Precision Glycomics: How AI and advanced mass spectrometry are changing the game Daniel Bojar, University of Gothenburg |
| 13:40 | Towards a universal molecular framework for structure prediction and design Patrick Bryant, SciLifeLab/Stockholm University (DDLS Fellow) Protein-ligand docking is an established tool in drug discovery and development to narrow down potential therapeutics for experimental testing. However, a high-quality protein structure is required and often the protein is treated as fully or partially rigid. Here we develop an AI system that can predict the fully flexible all-atom structure of protein-ligand complexes directly, given a multiple sequence alignment representation of the protein, protein pocket information, and a SMILES string representing the ligand. |
| 14:10 | Integrating single-cell transcriptomics with cellular phenotypes Joan Camuñas, University of Gothenburg |
| 14:40 | Thermodynamics-informed modeling of biochemical reaction and regulation networks Edda Klipp, Humboldt-Universität zu Berlin |
| 15:20 | Coffee Break |
| 15:50 | Tumor biology using multiomics Anders Ståhlberg, University of Gothenburg |
| 16:10 | Multiomics – state of art data generation and analysis at NGI Mattias Ormestad and Franziska Bonath, National Genomics Infrastructure Multiomics projects can span over long time frames, sometimes years, until all data is created. Often sequencing is an integral part and is outsourced to a core facility like NGI. For projects in which data generation is performed by different groups, it is crucial that important information about library preparation, sequencing and analysis is recorded and available to all other participants. Therefore, NGI applies quality control measures and reports important metadata to ensure that our users can use our data with confidence even years after data generation. |
| 16:30 | Data-Driven Microscopy: the automation of end-to-end imaging workflows Elisabet Carlsohn and Rafael Camacho, SciLifeLab/University of Gothenburg Biological complexity mandates comprehensive imaging for statistically significant results. Manual operation impedes large dataset acquisition, affecting reproducibility. Smart microscopy, integrating image analysis and computer-controlled microscopes, streamlines workflows. At GU’s Centre for Cellular Imaging, we offer open-access “smart microscopy” services optimizing data management with next-gen file formats, ome-zarr, community-driven visualization tools, napari, and collaborative platforms, webknossos. This ensures efficient resource utilization in the era of data-driven life sciences. |
| 17:00 | Tour to SciLifeLab units in Gothenburg Optional, sign up in registration form |
| 18:00 | Dinner for CMB fellows and experts, and speakers |
Friday, April 26
| April 26 | |
|---|---|
| 07:30 | Bus transport to Astra Zeneca Conference Centre in Mölndal |
| 08:00 | Visitor registration Astra Zeneca Conference Centre in Mölndal |
| 08:25 | Introduction Ola Engkvist, AstraZeneca & Margit Mahlapuu, University of Gothenburg |
| 08:30 | Empowering data-driven innovations in Life Sciences: A journey with GU Ventures Klementina Österberg, GU Ventures & Carl-Peter Mattsson, GU Ventures Klementina Österberg CEO & Carl-Peter Mattsson Investment director at GU Ventures will present their experiences and the journeys to create successful new business in collaborations with investors, industry and the eco system. They will also show some examples of these journeys with their companies. |
| 09:15 | BioVentureHub – an antidote to the incubent’s curse Magnus Björsne, AstraZeneca BioVentureHub |
| 10:00 | Coffee Break |
| 10:30 | Precision Medicine from the start – using omic data to deliver actionable insight to drug discovery and development Daniel Muthas, AstraZeneca |
| 11:15 | Data driven life sciences in a clinical setting Jesper Havsol, AstraZeneca |
| 12:00 | Networking lunch |
| 12:40 | Tour – “The Amazing Journey the story about Astra Zeneca in Mölndal” Optional, sign up in registration form |
Data-driven Life Science
The future of life science is data-driven, providing major new opportunities to explore and understand biology, human health and changing ecosystems. The SciLifeLab & Wallenberg National Program for Data-Driven Life Science (DDLS) is set up to make use of these opportunities.
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