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The evolution of human Genome Scale Metabolic models

April 22, 2021, 15:00 - 16:00
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Organizer

Rui Benfeitas, SciLifeLab/Stockholm University
rui.benfeitas@scilifelab.se
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The evolution of human Genome Scale Metabolic models

Virtual Event Virtual Event

April 22 @ 15:00 16:00 CEST

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Jonathan Robinson, Scientific Data Developer Bioinnovation Institute, Denmark

When: April 22, 15:00

Zoom: https://stockholmuniversity.zoom.us/j/68215564760

Host: Rui Benfeitas, Stockholm University

Abstract

Metabolism provides the energy and building blocks necessary to support life, but the complexity of the metabolic network presents a challenge when trying to determine how changes to one component affects the system as a whole. Genome-scale metabolic models (GEMs) were developed to address this challenge by providing computational reconstructions of metabolic networks. GEMs have been developed for hundreds of species including humans, supporting new approaches to study human health and disease.
In my talk, I will present our work in developing the most recent human GEM, Human1, and the different ways in which the model can be used to interpret omics data in a metabolic context. I will also share the challenges that we faced while developing Human1, and the challenges that we still face over a year after its initial release in 2020. Finally, I will discuss how we envision the future of GEMs, and our efforts to make them more accessible and useful for bioinformaticians.