I am interested in the interface between structural biology, protein interactions and assembly, and polymer science, with a focus on how molecular dynamics establish interactions between biomolecules.

This research involves identifying suitable fine-grained units for describing biological macromolecules and deriving preferably closed-form mean-field thermodynamic equations that can predict biological association and dissociation.

We also apply concepts of miscibility to describe protein protein interactions. The method has been successful in predicting survivin binding on peptide microarrays and in associating groups of proteins with functional annotations.

Ultimately, we aim to explain the molecular mechanisms and dynamics that underlie the mean-field parameters, and how these same mechanisms can sometimes drive folded structure formation.

Group Members

Torbjörn Nur Olsson