Adnane Achour

Key publications

Marc Panas, Tim Schulte, Bastian Thaa, Tatyana Sandalova, Nancy Kedersha, Adnane Achour and Gerald McInerney (2015) Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formation. Plos Pathogens, 11(2):e1004659.

Miguel Angel Burguillos, Martina Svensson, Tim Schulte, Albert Garcia-Quintanilla, Edel Kavanagh, Martiniano Santiago, Antonio Boza-Serrano, Nikenza Viceconte, Maria Jose Oliva-Martin, Emma Salomonsson, Lahouari Amar, Anette Persson, Adnane Achour, Elisabet Englund, Hakon Leffler, Jose Luis Venero, Bertrand Joseph and Tomas Deierborg (2015) Microglia-secreted Galectin-3 acts as a Toll-like receptor-4 ligand and contributes to microglial activation. Cell Reports, 10, 1626-1638.

Johan Grunewald, Ylva Kaiser, Mahyar Ostadkarampour, Natalia V. Rivera, Francesco Vezzi, Britta Lötstedt, Rémi-André Olsen, Lina Sylwan, Sverker Lundin, Max Käller, Tatiana Sandalova, Kerstin Ahlgren, Jan Wahlström, Adnane Achour, Mark Ronninger and Anders Eklund (2015) T cell receptor-HLA-DRB1 associations suggest specific antigens in pulmonary sarcoidosis. European Respiratory Journal, doi: 10.1183/13993003.01209-2015.

Elien M. Doorduijn, Marjolein Sluijter, Bianca J. Querido, Claudia C. Oliveira, Adnane Achour, Ferry Ossendorp, Sjoerd H. van der Burg and Thorbald van Hall (2016) Absence of central tolerance enables therapeutic exploitation of a CD8 T cell subset targeting hidden self-antigens. Journal of Clinical Investigation, 126(2):784-94.

Ida Hafstrand, Elien Doorduijn, Adil Doganay Duru, Jeremie Buratto, Claudia C. Oliveira, Tatyana Sandalova, Thorbald van Hall and Adnane Achour (2016) The MHC class I cancer-associated neo-epitope Trh4 linked with impaired peptide processing reveals a unique non-canonical TCR conformer. Journal of Immunology, 196(5):2327-34.

Adnane group

Research interests

Cellular communication is achieved through the interactions of specialized receptor molecules at the cell surface and their ligands. Our research group uses X-ray crystallography and Small Angle X-ray Scattering (SAXS) to study receptor-ligand interactions between T or NK cell receptors and Major Histocompatibility Complex (MHC) molecules, as well as bacterial adhesins and virulence-associated molecules.

All of our studies are complemented by a wide array of immunological assays as well as an extensive amount of biochemical techniques, including surface plasmon resonance and circular dichroism. By understanding the structural details of proteins, we can probe their function and potentially design artificial ligands that could modulate their function and activity.

Development of MHC class I-binding altered peptides for vaccines
Using a combination of structural biology and immunology, our research group has defined a procedure that allows for the design of altered peptide ligands (APLs) that bind with high affinity to MHC-I ligands. The immunogenic APLs act as mimotopes of disease-associated non-immunogenic epitopes, and enhance the stability of MHC-I molecules. Importantly, these modified peptides conserve a structural conformation similar to the wild-type infection-derived or non-immunogenic tumor-associated peptides. The induced immunogenic CD8+ T cells cross-react with the original peptides, resulting in enhanced responses. Studies of consequences of substitutions in APLs on CD8 responses directed towards tumor associated antigens and viral immune escape variants are ongoing.

Determination of the crystal structures of Streptococcus pneumoniae-associated virulence factors
Streptococcus pneumoniae (pneumococcus) is a major human pathogen and the leading cause of pneumoniae, bacteremia and meningitis in adults. The increasing number of antibiotic-resistant strains and the suboptimal clinical efficacy of available vaccines hamper control of this pathogen. We focus on novel virulence-related pneumococcal proteins that could be used as potential targets for future drugs.

Determination of the crystal structures of main allergens
Our research group has a strong interest in determining the crystal structures of allergens that provide important information regarding the initiation of allergy responses. These three-dimensional structures are used as templates for the design of hypoallergenic variants and to identify main antibody epitopes.

Group members

Jeremie Buratto, PhD, post-doc
Anatoly Dubnovitsky, PhD, senior scientist
Christina Gerstner, PhD student
Ida Hafstrand, PhD student
Xiao Han, PhD, post-doc
Gennady Kozhukh, PhD, senior scientist
Tatyana Sandalova, PhD, senior scientist
Tim Schulte, PhD, post-doc
Renhua Sun, PhD, post-doc

Key publications


Last updated: 2023-01-23

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