The clinical microfluidics Lab (Cm-Lab)
KTH Royal Institute of Technology
Clinical diagnostics is one of the fastest developing areas for microfluidic applications. Microfluidics has the potential to spur the development of protocols and affordable instruments for specific blood analyses with minimal perturbation of individual cell populations. The Clinical microfluidics Lab (Cm-Lab) is developing different microfluidic based point-of-care devices for blood diagnostics. Focus is on sample preparation and integration with nucleic acid analysis. We are currently working on cell sorting for (i)cancer, (ii)allergy and (iii)HIV diagnostics as well as bacteria isolation for blood stream infections; In addition, we are developing different platforms for low cost molecular diagnostics, such as “Lab-on-DVD” and “Lab-on-Foil” platforms. The Lab-on-DVD platform, the group has converted a Standard DVD drives to act as a laser scanning microscope for low-cost cellular and molecular diagnostics. Cm-Lab has a number of national and international collaboration projects, and we are currently involved in three EU projects (CanDo, RAPPID and Digital Sequencing).
Aman Russom, PhD; Associate Professor, Group Leader of Clinical Microfluidics Lab
Sergey Zelenin, PhD; Senior researcher
Harisha Ramachandraiah, PhD-student
Asim Faridi, PhD-student
Zenib Aljadi, PhD-student
Anna Ohlander, PhD-student
Wang Zhang, PhD-student
Frida Kalm, PhD-student
Indradumna Banerjee, PhD-student
David Walsh, PhD-student (exchange with Northeastern University, Boston USA)
- Zelenin, Sergey, Jonas Hansson, Sahar Ardabili, Harisha Ramachandraiah, Hjalmar Brismar, and Aman Russom. “Microfluidic-based isolation of bacteria from whole blood for sepsis diagnostics.” Biotechnology letters , 2014: 1-6.
- Ramachandraiah, Harisha, Sahar Ardabili, Asim M. Faridi, Jesper Gantelius, Jacob M. Kowalewski, Gustaf Mårtensson, and Aman Russom. “Dean flow-coupled inertial focusing in curved channels.” Biomicrofluidics, 2014, 8, no. 3: 034117.
- Harisha Ramachandraiah , Mary Amasia , Jackie Cole , Paul Sheard , Simon Pickhaver , Chris Walker , Valtteri Wirta , Preben Lexow , Richard Lione and Aman Russom. Lab-on-DVD: standard DVD drives as a novel laser scanning microscope for image based point of care diagnostics. Lab on a Chip, 2013, 13 (8), 1578 – 1585*
- Anna Ohlander, Caterina Zilio, Tobias Hammerle, Sergey Zelenin, Gerhard Klink, Marcella Chiari, Karlheinz Bock and Aman Russom. Genotyping of single nucleotide polymorphisms by melting curve analysis using thin film semi-transparent heaters integrated in a lab-on-foil system; Lab Chip, 2013, 13, 2075 2082**
- Jonas Hanssona, Mikael Karlsson, Tommy Haraldsson, Hjalmar Brismara, W. van der Wijngaart, and Aman Russom. Inertial microfluidics in parallel channels for high-throughput applications. Lab on a Chip, 2012, 12, 4644-4650
* Highlighted by Nature Photonics and has been covered in news outlets in more than 24 countries.
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