Ana Luis

University of Gothenburg

Key publications

Luis AS, Hansson GC.
Intestinal mucus and their glycans: A habitat for thriving microbiota.
Cell Host Microbe. 2023 Jul 12;31(7):1087-1100. PMID: 37442097

Raba G, Luis AS.
Mucin utilization by gut microbiota – recent advances on characterization of key enzymes.
Essays in Biochemistry. 2023 Apr 18;67(3):345-353. PMID: 36695502

Luis AS, Basle A, Byrne DP, Wright GSA, London J, Jin C, Karlsson NG, Hansson GC, Eyers PA, Czjzek M, Barbeyron T, Yates EA, Martens EC, Cartmell A.
Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota.
Nature Chemical and Biology. 2022 Jun 16. PMID: 35710619.

Luis AS, Jin C, Pereira GV, Glowacki RWP, Gugel S, Singh S, Byrne DP, Pudlo N, London JA, Basle A, Reihill M, Oscarson S, Eyers PA, Czjzek M, Michel G, Barbeyron T, Yates EA, Hansson GC, Karlsson NG, Cartmell A, Martens EC.
A single sulfatase is required to access colonic mucin by a gut bacterium.
Nature. 2021 Oct;598(7880):332-337. PMID: 34616040.

In the healthy colon, the mucus layer creates a physical barrier that limits the contact between the microbiota and the host tissue to prevent inflammation. The major component of the mucus layer is mucin, a large glycoprotein that is heavily O-glycosylated. Our research is focused on understanding the basic mechanisms of interaction between microbiota and human colonic mucins.

We are currently particularly interested in:

functional and structural characterization of microbiota O-glycan active enzymes
identification of key binding domains utilized by commensal bacteria to select their host
characterization of the mechanisms of utilization of human colonic mucins by microbiota members  study the impact of diet on mucin glycosylation and mucus barrier function

Last updated: 2024-01-26

Content Responsible: Hampus Persson(