induced Pluripotent Stem Cell (iPSC) is a unique cell type due to its ability to expand massively, long-term stored maintaining its ability to differentiate into all cell types of the human body. Thus, iPSCs are optimal for creating cellular models of human organs and for deriving cell therapies to replace dead or injured cell. iPSC can be established from human skin of any individual, the intact genome is maintained and if specific genes are to be studied CRISPR editing of iPSC is powerful.
Anna Falk
Lund University
Keywords
Key Publications
Acute doses of caffeine shift nervous system cell expression profiles toward promotion of neuronal projection growth.
Scientific reports, 2017
An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis.
Molecular psychiatry, 2017
Integration Free Derivation of Human Induced Pluripotent Stem Cells Using Laminin 521 Matrix.
Journal of visualized experiments : JoVE, 2017
Derivation of human iPS cell lines from monozygotic twins in defined and xeno free conditions.
Stem cell research, 2017
TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells.
Cell reports, 2017