The Aristidis Moustakas group is a molecular and cell biology research unit with special expertise in signal transduction and cell differentiation. We study these biological processes in the context of cancer. This approach generates significant opportunities for the generation of new methods of treating cancers, collectively called differentiation therapy methods.
More specifically our research focuses on some of the major signal transduction pathways, namely the transforming growth factor β (TGFβ) and the related bone morphogenetic protein (BMP) pathway, which play central roles in controlling the differentiation of many cell types. The TGFβ/BMP pathways also take central stage in the progression and ultimate metastasis of essentially all tumors. The research scans several tumor types, breast, lung, liver cancer and brain tumors, aiming at uncovering common, general principles that drive the behavior of these tumor types. Our research group gradually maps the complex signaling routes and their connections to transcription factors and gene networks that orchestrate the behavior of malignant cells.
Anita Morén, Senior technician
Chrysoula Tsirigoti, PhD stud.
Caroline Gélabert, PhD stud.
Laia Caja Puigsubirà, Researcher.
Yae Ohata, postdoc.
Irene Golàn Cancela, Researcher.
Dorival Mendes Rodrigues Jr., postdoc.
Mohamad Moustafa Ali, postdoc.
Maria Peleli, postdoc.
Yuka Itoh, visiting researcher.
Diana Öz, MSc student.
Ayana Nakada, visiting student.