Forskningsbild Bjorn Onfelt

Research interests

We use microchip techniques for live cell imaging and screening to characterize immune response at the single cell level. T cell and natural killer (NK) cells have remarkable abilities to mediate targeted attack against virus-infected or malignant cells. In adoptive cell therapy these qualities are used to treat primary malignancies, life-threatening virus infections or leukemic relapses after allogeneic hematopoietic stem cell transplantation. Although this therapy has shown promising results we have only a remote understanding of how to utilize T and NK cells to their full potential. A major challenge is to select and prepare cells that mediate anti-tumor effects without causing life-threatening side effects such as graft versus host disease. By better understanding of how populations of NK cells and T cells are built up by individual cells with varying capacity to respond to stimuli we will be able to improve current methods for immunotherapy.

Group members

Björn Önfelt, Professor, PI
Karolin Guldevall, Researcher
Niklas Sandström, Postdoc
Patrick Sandoz, Postdoc
Laura Sanchez Rivera, Postdoc
Rento Alves, Postdoc
Ludwig Brandt, PhD-student
Quentin Verron, PhD-student
Valentina Carannante, PhD-student
Hanna van Ooijen , PhD-student
Karl Olofsson, PhD-student (cosupervisor)

Contact

bjorn.onfelt@scilifelab.se

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Ok!Read More
Privacy & Cookies Policy

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary
Always Enabled

Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.

Non-necessary

Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.