Carina Schlebusch

Key Publications

Fortes-Lima CA#, Burgarella C#, Hammarén R#, Eriksson A, Vicente M, Jolly C, Semo A, Gunnink H, Pacchiarotti S, Mundeke L, Matonda I, Muluwa JK, Coutros P, Nyambe TS, Cikomola C, Coetzee V, de Castro M, Ebbesen P, Delanghe J, Stoneking M, Barham L, Lombard M, Meyer A, Steyn M, Malmström H, Rocha J, Soodyall H, Pakendorf B, Bostoen K, Schlebusch CM (2024) The genetic legacy of the expansion of Bantu-speaking peoples in Africa. Nature Nov 29:1-8.

Jakobsson M#, Bernhardsson C, McKenna J, Hollfelder N, Vicente M, Edlund H, Coutinho A, Sjödin P, Brink J, Zipfel B, Malmström H, Lombard M#, Schlebusch CM# (2025) Homo sapiens-specific evolution unveiled by ancient southern African genomes. Nature. 2025 Dec 3:1-8.

MC Ávila-Arcos#, M Raghavan#, CM Schlebusch# (2023) Going local with ancient DNA: A review of human histories from regional perspectives. Science 382(6666): 53-58

CM Schlebusch#, H Malmström#, T Günther, P Sjödin, A Coutinho, H Edlund, A Munters, M Vicente, M Steyn, H Soodyall, M Lombard, M Jakobsson (2017) Southern African ancient genomes estimate modern human divergence to 350,000 to 260,000 years ago. Science 358:652-655

CM Schlebusch#, P Skoglund#, P Sjödin, LM Gattepaille, D Hernandez, F Jay, S Li, M De Jongh, A Singleton, MGB Blum, H Soodyall, M Jakobsson (2012) Genomic variation in seven Khoe-San groups reveals adaptation and complex African history. Science 338:6105 p374-379
M Vicente & CM Schlebusch (2020) African population history: an ancient DNA perspective. Current opinion in genetics & development 1(62):8-15

My research focuses on human evolutionary genetics, with a particular emphasis on African population history. I use genome-wide data from present-day and ancient individuals to investigate how deep population structure, migration, and admixture have shaped genetic diversity across Africa. A central aim of my work is to better understand the origins and diversification of our species, Homo sapiens, within Africa, and how these processes relate to major cultural and environmental transitions.

A second core research interest is the integration of ancient DNA with archaeology, linguistics, and historical data to study demographic processes such as the spread of food production, pastoralism, and large-scale population movements, including the Bantu expansion. By combining genetic data with interdisciplinary evidence, I aim to develop more nuanced models of population interactions and continuity over time.

More recently, my research has expanded to include the evolution of pathogens and human–pathogen interactions in deep time. Using ancient DNA, I investigate past infectious diseases in Africa and how changes in lifestyle, environment, and population structure influenced pathogen emergence and spread. Overall, my work seeks to link human demographic history with health, disease, and adaptation in both past and present populations.

Group Members

Francesco Giannelli
Cecile Jolly
Bupe Kapema
Grace Kennedy
Jules Koelman
Imke Lankheet
Andrea Soler i Núñez
Johanna von Seth
Maja Vukovikj
Modeste Zeye

Last updated: 2025-12-17

Content Responsible: Hampus Pehrsson Ternström(hampus.persson@scilifelab.uu.se)