Our interests focus on the understanding of the molecular basis of diseases through translational research, specifically, but not exclusively, related to inflammation. The key aspects of our work include genome-wide gene expression analysis from human patient samples employing technologies such as RNA-Seq, Cap Analysis of Gene Expression (CAGE) or small RNA sequencing. Our analysis goes beyond differentially expressed genes and identifies a variety of candidate elements responsible for the observed expression differences in the disease patients and the associated clinical phenotypes. Application of sequencing technology to the transcriptome previously has been utilized to uncover a range of regulatory elements and mechanisms, including regulation through transcription factors (TFs), nearby but distinct alternative promoters resulting in the same protein but employing different sets of regulatory TFs, expression of anti-sense RNA to modulate the sense-RNA and the regulatory role of expressed repeat elements and miRNAs. Subsequent functional validation studies confirm the suggested regulatory relationships.
Carsten O. Daub, PI
Niyaz Yoosuf, Postdoc
Enrichetta Mileti, PhD student
Tahmina Akhter, PhD student
Abdul Kadir Mukarram, PhD student
Matthias Hörtenhuber, PhD student
Previous group members
Olga Hrydziuszko, Postdoc (2012-2014)
Amitha Raman, Laboratory technician (2012-2014)
Nancy Yu, Postdoc (2012-2014)
Wenjing Kang, Masters student (Feb-June 2014)
Jacqueline Nowak, Masters student (April-August 2014)
Kubra Altinel, Erasmus summer student, 2014
Johanna Labate, Erasmus summer student, 2015
Graduated PhD students
Morana Vitezic, 2013
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