Cecilia Engdahl

Key publications

Reduction of mature B cell and immunoglobulins results in increase trabecular bone 
Lagerquist MK, Gupta P, Sehic E, Horkeby KL, Scheffler JM, Nordqvist J, Lawenius L, Islander U, Corciulo C, Henning P, Carlsten H, Engdahl C
J Bone Miner Res Plus, 2022 Aug30;6(9)10670

Immunoglobulin G complexes without sialic acids enhance osteoclastogenesis but do not affect arthritis-mediated bone loss
Sehic E, Westerlund A, Lagerquist MK, Carlsten H, Lerner U, Henning P, Engdahl C.
Scandinavian Journal of Immunology, 2021 May;93(5)

Changes in mechanical loading affect arthritis-induced bone loss in mice
Liphardt AM, Windahl SH, Sehic E, Hannemann N, Gustafsson KL, Bozec A, Schett G, Engdahl C.
Bone, 2020 Feb;131:115149

Estrogen induces St6gal 1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis- a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women
Engdahl C, Bondt A, Harre U, Raufer J, Pfeifle R, Camponeschi A, Wuhrer M, Seeling M, Mårtensson I-L, Nimmerjahn F, Krönke G, Scherer H.U, Forsblad-d’Elia H, Schett G.

Periarticular bone loss in arthritis is induced by autoantibodies against citrullinated vimentin
Engdahl C, Bang H, Dietel K, Lang C.S. Harre U, Schett G.
J Bone Miner Res 2017 Aug;32(8):1681-1691

Periarticular bone loss in antigen-induced arthritis
Engdahl C, Lindholm C, Stubelius A, Ohlsson C, Carlsten H, Lagerquist MK.
Arthritis Rheum, 2013 Nov;65(11):2857-65

Negative regulation of the skeleton tissue has been neglected in finding and implementing sufficient treatment for other conditions. Although senescence and female gender are established risk factors for primary osteoporosis. The aging population of today coupled with improved survival rates from diseases and conditions that have secondary effects on bone further increases the risk of fractures, especially in Scandinavia, which has the highest risk of osteoporotic fractures globally.

Our focus is on the secondary effect of radiation, massive apoptosis within the bone marrow, as well as in autoimmune conditions, and combined this with a decrease in sex steroids. Specifically, we are interested in osteoclasts, the bone-resorbing cells that derive from hematopoietic stem cells via monocyte-lineage precursor cells. While sharing characteristics with other macrophages and dendritic cells, recent research indicates that osteoclasts not only resorb bone but may also play a crucial role in immune activation in the bone marrow. Osteoclasts are stimulated by pro-inflammatory cytokines induced by immune responses, as well as by antibodies, especially non-glycosylated extra-pathogenic antibodies. Furthermore, we examine how osteoclast capacity is influenced by apoptotic dead cells.

Group members

Tibor Sàghy
Priti Gupta
Merja Nurkkula-Karlsson
Malin Erlandsson

Last updated: 2023-04-03

Content Responsible: Hampus Persson(hampus.persson@scilifelab.uu.se)