The rapid development of single cell omics technology has opened a new possibility of precision and translational medicine. My research group mainly focuses on integration and interpretation of single cell omics data with the help of systems biology tools such as multi-omics networks and genome-scale metabolic models. The aim is to reveal molecular mechanisms of complex disease whose development and progression may involve interplays with multiple cell types. In addition, key pathways and hub genes will also be identified which could be used as novel biomarkers or drug targets for diagnosis and treatment of individual patients. Currently, my group works on projects that investigate liver cirrhosis, renal fibrosis, and colon cancer.
Mengnan Shi, PhD student