My team works with drug delivery, where knowledge of physiological pathways are used to improve delivery of pharmacologically active compounds to the site of action. We work multidisciplinary within pharmaceutics, material sciences, physical chemistry and physiology, and make use of advanced computational modelling, develop novel in vitro tools and design new type(s) of drug carriers in our quest for better medicines.
Christel Bergström
Head of Unit: ADME of Therapeutics, Uppsala University
Keywords
computational modelling and simulation, dissolution-digestion-permeation models, drug delivery, formulation, in vitro in vivo correlation, macromolecules, molecular pharmaceutics, oral dosage forms, poorly permeable compounds, poorly water-soluble compounds, pulmonary delivery, virtual formulation design
Key Publications
Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems
Molecular Pharmaceutics, 2025
Impact of surfactants on solution behavior and membrane transport of amorphous solid dispersions
Journal of Pharmaceutical Sciences, 2025
Effect of Data Quality and Data Quantity on the Estimation of Intrinsic Solubility: Analysis Based on a Single-Source Data Set
Molecular Pharmaceutics, 2024
Development of a canine artificial colonic mucus model for drug diffusion studies
European Journal of Pharmaceutical Sciences, 2024
Experiences and Translatability of In Vitro and In Vivo Models to Evaluate Caprate as a Permeation Enhancer
Molecular Pharmaceutics, 2024