Christos Samakovlis

Scientfic Director SciLifeLab, Professor, Stockholm University

Key publications

Yao L, Wang S, Westholm JO, Dai Q, Matsuda R, Hosono C, Bray S, Lai EC, Samakovlis C. Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl. Development. 2017 Sep 1;144(17):3145-3155. doi: 10.1242/dev.143297

Hosono C, Matsuda R, Adryan B, Samakovlis C. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Nat Cell Biol 2015, 17:1569-1576.

Matsuda R, Hosono C, Samakovlis C, Saigo K. Multipotent versus differentiated cell fate selection in the developing Drosophila airways. Elife 2015, Pii:e09646

Matsuda R, Hosono C, Saigo K, Samakovlis C. The intersection of the extrinsic hedgehog and WNT/Wingless signals with the intrinsic Hox code underpins branching pattern and tube shape diversity in the drosophila airways. PLoS Genet 2015, 11:e1004929.

O’Farrell F, Wang S, Katheder N, Rusten TE, Samakovlis C. Two-tiered control of epithelial growth and autophagy by the insulin receptor and the ret-like receptor, stitcher. PLoS Biol 2013, 11:e1001612

Research interests

Lung Development and Regeneration
Epithelial cells in the lung form a highly organized tubular network exposed to air, pollutants and pathogens to facilitate breathing. To elucidate the genetic blueprint of airway cell differentiation and morphogenesis we use the powerful genetic tools available in Drosophila airways combined with live imaging and single cell transcriptomics in the mouse lung. A major aim is to identify the cellular heterogeneity and plasticity in the lung epithelium during homeostasis and upon injury or infection. Mechanistic studies in flies, showed that the selection of differentiated and multipotent stem cells in the airway tree relies on a sensitive balance of Wingless, Hedgehog and RTK signaling. Our single cell mRNA sequencing of lung epithelial cells and in situ sequencing experiments in mice revealed a large variety of airway cells and their candidate cell fate regulators. We now use mouse genetics, live imaging of mouse lung slices and cultures of human bronchial cells to probe the regulatory circuits that select and maintain distinct populations of stem- and differentiated cells.

Lung diseases, including cancer are among the leading causes of death worldwide with still unmet treatment challenges. Using high-resolution, single cell analysis technologies we hope to understand the cellular and molecular programs leading to normal lung development and to discover how these programs become misdirected to cause terminal lung diseases.

Group members

Alexandros Sountoulidis Ph.D, senior postdoc
Elpidophoros Sakkas, Ph.D, postdoc
Alexandra Firsova, Ph.D, postdoc
Hong Phuong-Nguyen, Ph.D, postdoc
Andreas Liontos, PhD student


Last updated: 2023-07-27

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