RNA is an indispensable molecule for every living organism and implicated in diverse biological processes. We study noncoding (long noncoding, transfer and small RNAs) and coding RNAs at the transcriptome-wide level in mammalian somatic tissues and in the germline. Our aim is to gain mechanistic insights into the transcriptional and post-transcriptional regulation and processing of RNAs during organ development, cell differentiation and disease progression.
Our objectives are:
- revealing the origin, evolution and disease association of noncoding RNAs (ncRNAs),
- deciphering the molecular mechanism underpinning regulation by ncRNAs and
- the functional validation of ncRNAs.
Our experimental approaches include:
- applying and developing high-throughput RNA sequencing methodologies and epigenetic profiling coupled to powerful computational analysis,
- detailed biochemical assays and
- phenotypic characterization using genome editing tools in mammalian cell lines and tissues.
We welcome enquiries (with CV) about experimental and computational postdoctoral positions.
Schmitt B.M., Rudolph K.L.M., Karagianni P., Fonseca N.A., White R.J., Talianidis I., Odom D.T.†, Marioni J.C.† and Kutter C.† “High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA–tRNA interface”. Genome Research (2014) 24(11), 1797-1807
Kutter C.*, Watt S.*, Stefflova K., Wilson M.D., Gonçalves A., Ponting C.P., Odom D.T. and Marques A.C. “Rapid turnover of long noncoding RNAs and the evolution of gene expression”. PLoS Genetics (2012) 8(7), e1002841
Kutter C.*, Brown G.D.*, Watt S., Wilson M.D., Gonçalves A., Brazma A., White R.J. and Odom D.T. “Pol III binding in six mammalian genomes reveals divergence in tRNA gene usage, despite high conservation among amino acid isotypes”. Nature Genetics (2011) 43(10), 948-955
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