Daniel Globisch

Associate Professor, Uppsala University

Key publications

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N‐Acetyltransferase NAT2
L. P. Conway, V. Rendo, M.S.P. Correia, I.A. Bergdahl, T. Sjöblom, D. Globisch
Angew. Chem. Int. Ed. 2020, 59, 14342-14346.

Chemoselective Probe Harboring a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism
N. Garg, L. P. Conway, C. Ballet, M. S. P. Correia, F. K. S. Olsson, M. Vujasinovic, J.-M. Löhr, D. Globisch
Angew. Chem. Int. Ed. 2018, 57, 13805 –13809.

New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
C. Ballet, M. S. P. Correia, L. P. Conway, T. L. Locher, L. C. Lehmann, N. Garg, M. Vujasinovic, S. Deindl, J.-M. Löhr, D. Globisch
Chem. Sci. 2018, 9, 6233–6239.
Featured in the 2018 Chemical Science HOT Article Collection

Chemoselective Probe for Detailed Analysis of Ketones and Aldehydes Produced by Gut Microbiota in Human Samples
L. P. Conway, N. Garg, W. Lin, M. Vujasinovic, J.-M. Löhr, D. Globisch
Chem. Comm. 2019, 55, 9080-9083.
Inside Back Cover

Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness
D. Globisch
, A. Y. Moreno, M. S. Hixon, A. A. K. Nunes, J. R. Denery, S. Specht, A. Hoerauf, K. D. Janda
Proc. Natl. Acad. Sci. U S A 2013, 110, 4218-4223.
Cover Image, Research Highlight in Nature 2013, 495, 8; News of the Week in Chem. & Eng. News 2013, 91, 11; Science Now in Science February 2013

Uncharacterized 4,5-Dihydroxy-2,3-Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species
D. Globisch
, C. A. Lowery, K. C. McCague, K. D. Janda
Angew. Chem. Int. Ed. 2012, 51, 4204–4208.
Inside Back Cover; Very Important Paper; Spotlight in ACS Chem. Biol. 2012, 7, 789−790; Highlight in Angew. Chem. Int. Ed. 2012, 51, 6314–6315.

Systems-Based Analysis of Modified tRNA Bases
D. Globisch
, D. Pearson, A. Hienzsch, T. Brückl, M. Wagner, I. Thoma, P. Thumbs, V. Reiter, A. C. Kneuttinger, M. Müller, S. A. Sieber, T. Carell
Angew. Chem. Int. Ed. 2011, 50, 9739–9742.

Research Interests

The Globisch lab is an international research group with focus on the development of new Chemical Biology-based methodologies to improve the analysis of small molecule metabolites in biological samples. These new methodologies are aimed at enhancing the scope of metabolomics-based research. In our multidisciplinary research we work at the interface of Chemistry and Biology with a combination of Organic Chemistry, Chemical Biology techniques, Biochemistry, mass spectrometric analysis of metabolites, and metabolomics. The discovery of specific early-stage biomarkers, new drug targets and the development of new therapeutic interventions are crucial for disease prevention and management towards personalized medicine.

Biomarker Discovery is a challenging and multidisciplinary task. We develop new tools for mass spectrometric analysis and are focussed on elucidating microbiota metabolism in the human host. We investigate any human sample type, e.g. fecal, urine, and plasma samples from pancreatic cancer patients.

Group members

  • Daniel Globisch, Associate Professor 
  • Mário Correia, PhD student 
  • Weifeng Lin, PhD student 
  • Ioanna Tsiara, PhD student 
  • Abhishek Jain, postdoctoral researcher 
  • Theodosia Vallianatou, postdoctoral researcher 
  • Amanpreet Kaur, postdoctoral researcher 
  • Weiming Zeng, Master’s student 
  • Zhen Yang, Master’s student 
  • Léna Driutti, Erasmus+ exchange student 
  • Spyke Schumacher, internship student



Last updated: 2022-11-30

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