Uppsala University

Research Interests

The discovery of specific early-stage biomarkers, new drug targets and the development of new therapeutic interventions are crucial for disease prevention and management towards personalized medicine. Analysis of metabolites in human specimen comprises a high potential for identification of unknown biomarkers, which can be utilized for the development of new diagnostics. Our interdisciplinary projects will focus on the development of new methodologies using techniques at the interface of chemistry and biology for an advanced quantitative and qualitative metabolome analysis to discover disease-specific metabolites.

Group members

Key publications

• C. Ballet+, M. S. P. Correia+, L. P. Conway, T. L. Locher, L. C. Lehmann, N. Garg, M. Vujasinovic, S. Deindl, J.-M. Löhr, D. Globisch Chem. Sci. 2018, 9, 6233–6239. “New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites”. Featured in the 2018 Chemical Science HOT Article Collection
• D. Globisch, A. Y. Moreno, M. S. Hixon, A. A. K. Nunes, J. R. Denery, S. Specht, A. Hoerauf, K. D. Janda Proc. Natl. Acad. Sci. U S A. 2013, 110, 4218-4223. “Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness”.
  Cover Image, Research Highlight in Nature 2013, 495, 8; News of the Week in Chem. & Eng. News 2013, 91, 11; Science Now in Science February 2013

• D. Globisch, C. A. Lowery, K. C. McCague, K. D. Janda Angew. Chem. Int. Ed. 2012, 51, 4204–4208. “Uncharacterized 4,5-Dihydroxy-2,3-Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species“.
  Inside Back Cover; Very Important Paper; Spotlight in ACS Chem. Biol. 2012, 7, 789−790; Highlight in Angew. Chem. Int. Ed. 2012, 51, 6314–6315.

• D. Globisch, D. Pearson, A. Hienzsch, T. Brückl, M. Wagner, I. Thoma, P. Thumbs, V. Reiter, A. C. Kneuttinger, M. Müller, S. A. Sieber, T. Carell Angew. Chem. Int. Ed. 2011, 50, 9739–9742. “Systems-Based Analysis of Modified tRNA Bases”.

• M. Münzel*, D. Globisch*, T. Brückl, M. Wagner, V. Welzmiller, S. Michalakis, M. Müller, M. Biel, T. Carell Angew. Chem. Int. Ed. 2010, 49, 5375–5377. “Quantification of the sixth DNA base hydroxymethylcytosine in the brain”.
  Highlight in Chem. Eng. News 2010, 88 (No 27), 24.

Funding

Contact

Daniel.Globisch@scilifelab.uu.se.

External homepage

Department of Medicinal Chemistry