Daniel Globisch


Daniel Globisch
Uppsala University

 

Research Interests

The Globisch lab is an international research group with focus on the development of new Chemical Biology-based methodologies to improve the analysis of small molecule metabolites in biological samples. These new methodologies are aimed at enhancing the scope of metabolomics-based research. In our multidisciplinary research we work at the interface of Chemistry and Biology with a combination of Organic Chemistry, Chemical Biology techniques, Biochemistry, mass spectrometric analysis of metabolites, and metabolomics. The discovery of specific early-stage biomarkers, new drug targets and the development of new therapeutic interventions are crucial for disease prevention and management towards personalized medicine.

Biomarker Discovery is a challenging and multidisciplinary task. We develop new tools for mass spectrometric analysis and are focussed on elucidating microbiota metabolism in the human host. We investigate any human sample type, e.g. fecal, urine, and plasma samples from pancreatic cancer patients.

 

Group members

Daniel Globisch, Associate Professor
Mário Correia, PhD student
Caroline Ballet, postdoctoral researcher
Louis Conway, postdoctoral researcher
Abhishek Jain, postdoctoral researcher
Weifeng Lin, Master’s student
Mia Elfström, internship student
Clara Hild, Erasmus+ exchange student
Samantha Sasse, Erasmus+ exchange student
Spyke Schumacher, internship student

 

 

Key publications

  • N. Garg+, L. P. Conway+, C. Ballet, M. S. P. Correia, F. K. S. Olsson, M. Vujasinovic, J.-M. Löhr, D. Globisch* Angew. Chem. Int. Ed. 2018, 57, 13805 –13809​. “Chemoselective Probe Harboring a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism”
  • C. Ballet+, M. S. P. Correia+, L. P. Conway, T. L. Locher, L. C. Lehmann, N. Garg, M. Vujasinovic, S. Deindl, J.-M. Löhr, D. Globisch* Chem. Sci. 2018, 9, 6233–6239. “New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites”. Featured in the 2018 Chemical Science HOT Article Collection
  • N. Garg, A. Hansson, H. K. Knych, S. D. Stanley, M. Thevis, U. Bondesson, M. Hedeland, D. Globisch* Org. Biomol. Chem. 2018, 16, 698-702. “Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control”.
  • D. Globisch, A. Y. Moreno, M. S. Hixon, A. A. K. Nunes, J. R. Denery, S. Specht, A. Hoerauf, K. D. Janda Proc. Natl. Acad. Sci. U S A 2013, 110, 4218-4223. “Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness”.
    Cover Image, Research Highlight in Nature 2013, 495, 8; News of the Week in Chem. & Eng. News 2013, 91, 11; Science Now in Science February 2013
  • D. Globisch, C. A. Lowery, K. C. McCague, K. D. Janda Angew. Chem. Int. Ed. 2012, 51, 4204–4208. “Uncharacterized 4,5-Dihydroxy-2,3-Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species“.
    Inside Back Cover; Very Important Paper; Spotlight in ACS Chem. Biol. 2012, 7, 789−790; Highlight in Angew. Chem. Int. Ed. 2012, 51, 6314–6315.
  • D. Globisch, D. Pearson, A. Hienzsch, T. Brückl, M. Wagner, I. Thoma, P. Thumbs, V. Reiter, A. C. Kneuttinger, M. Müller, S. A. Sieber, T. Carell Angew. Chem. Int. Ed. 2011, 50, 9739–9742. “Systems-Based Analysis of Modified tRNA Bases”.

 

Contact

Daniel.Globisch@scilifelab.uu.se.

 

External homepage

Department of Medicinal Chemistry (http://www.ilk.uu.se/research-groups/biomarker-discovery/)

Twitter

@GlobischLab