My own research probes biological structure-function relationships using X-ray and neutron diffraction, cryo-electron microscopy, small-angle X-ray scattering, cross-linking mass spectrometry, biophysical and biochemical analyses. Two particular current focus areas are allosteric regulation of the essential enzyme ribonucleotide reductase, at both the enzyme and transcriptional levels, as well as drug design against the galectin family of carbohydrate binding proteins.
Derek Logan
Lund University
Key Publications
A truncated CDC14A retains catalytic structure and phosphatase activity preserving male fertility but causes nonsyndromic deafness
The Journal of biological chemistry, 2026
Regulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15
Nature Communications, 2025
A single residue affects the dynamics and shape of a tetrameric GH43 β‐1,4‐d‐xylosidase from Levilactobacillus brevisDSM1269
Protein Science, 2025
Bacterial transcriptional repressor NrdR – a flexible multifactorial nucleotide sensor
The FEBS Journal, 2025
Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction
Communications Chemistry, 2025