Dmitri Ossipov

Head of Unit: Oligonova (Chemistry), University of Gothenburg

Key publications

1) Poly (vinyl alcohol)-based hydrogels formed by “click chemistry”. DA Ossipov, J Hilborn. Macromolecules 39 (5), 1709-1718

2) Self‐healing silk fibroin‐based hydrogel for bone regeneration: dynamic metal‐ligand self‐assembly approach. L Shi, F Wang, W Zhu, Z Xu, S Fuchs, J Hilborn, L Zhu, Q Ma, Y Wang, … Advanced Functional Materials 27 (37), 1700591

3) In situ cross-linkable high molecular weight hyaluronan− bisphosphonate conjugate for localized delivery and cell-specific targeting: a hydrogel linked prodrug approach. OP Varghese, W Sun, J Hilborn, DA Ossipov. Journal of the American Chemical Society 131 (25), 8781-8783

4) Bisphosphonate nanoclay edge-site interactions facilitate hydrogel self-assembly and sustained growth factor localization. YH Kim, X Yang, L Shi, SA Lanham, J Hilborn, ROC Oreffo, D Ossipov, … Nature communications 11 (1), 1365

My research interests are centered around chemical modifications of oligonucleotides that improve their therapeutic potential via solving problems of specific tissue targeting, cellular uptake, and intracellular trafficking. An integral part of the research is active use of polymeric biomaterials in drug delivery through different kinds of polymer-oligonucleotide association (covalent, electrostatic, metal coordination, physical encapsulation). 

Group Members:

Christian Pett
Maksim Kvach

Last updated: 2024-12-04

Content Responsible: Hampus Persson(hampus.persson@scilifelab.uu.se)