The main focus of the lab is to use organic chemistry, medicinal chemistry, and chemical biology to explore new strategies to interfere with and study processes related to cancer biology. This includes the development of small heterocyclic molecules but also new modalities in drug development such as oligonucleotides. The bioactive derivatives are designed using structure-based techniques or identified through screening-based strategies with Chemical Biology Consortium Sweden.
Erik Chorell
Umeå University
Key Publications
Linker Design Principles for the Precision Targeting of Oncogenic G-Quadruplex DNA with G4-Ligand-Conjugated Oligonucleotides
Bioconjugate Chemistry, 2025
Design, Synthesis, and Biophysical Characterization of Pyridine Bis‐Quinazoline Derivatives as Selective G‐Quadruplex DNA Stabilizers
Chemistry – A European Journal, 2025
Exploring i-Motif DNA binding with benzothiazolino Coumarins: Synthesis, Screening, and spectroscopic insights
Bioorganic Chemistry, 2025
G4-Ligand-Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures
Journal of the American Chemical Society, 2024
Exploring the Dispersion and Electrostatic Components in Arene–Arene Interactions between Ligands and G4 DNA to Develop G4-Ligands
Journal of Medicinal Chemistry, 2024