Felipe Cava

Key publications

Undecaprenyl phosphate translocases confer conditional microbial fitness
Sit B, Srisuknimit V, Bueno E, Zingl FG, Hullahalli K, Cava F#, Waldor MK#
Nature. 2023 Jan;613(7945):721-728.

Peptidoglycan recycling mediated by an ABC transporter in the plant pathogen Agrobacterium tumefaciens
Gilmore MC, Cava F#
Nature Communications. 2022 Dec 24;13(1):7927.

BipA exerts temperature-dependent control of biofilm-associated colony morphology in Vibrio cholerae
Del Peso T, Alvarez L, Sit B, Irazoki I, Blake J, Warner BR, Warr AR, Bala A, Benes V, Waldor MK, Fredrick K and Cava F#
Elife. 2021 Feb 12;10:e60607

Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides
Hernandez S, Dörr T, Waldor MK and Cava F#
Cell Reports 2020 Apr 28;31(4):107578.

Anaerobic nitrate reduction divergently governs population expansion of the enteropathogen Vibrio cholerae
Bueno E, Sit B, Waldor MK and Cava F#
Nature Microbiology. 2018 Dec; 3(12):1346-1353.

Bacterial secretion of D-arginine controls environmental microbial biodiversity
Alvarez L, Aliashkevich A, de Pedro MA and Cava F#
ISME J. 2018 Feb;12(2):438-450.

My lab in Umeå University/MIMS-UCMR aims at deciphering new knowledge on one of the major “Achilles heels” of bacteria – their cell wall – both to provide answers to scientific fundamental questions and to improve our options to combat long-standing and emerging infectious diseases. We use an arsenal of advanced analytical technologies and cell imaging tools (optical, fluorescence and correlative SEM-FL microscopy, MATLAB and ImageJ based image analysis), combined with genetics and next generation sequencing technologies (including RNA-seq, Tn-seq), biochemistry, bioinformatics (MATLAB and R based-chemometrics) and molecular biology to study how bacteria regulate their cell wall to adapt to (and infect) the host in some of the most relevant bacterial models.

To approach this, we have launched an integrative research program to uncover and exploit the unnoticed variability of the bacterial cell wall. This investigation is imperative for a realistic understanding of cell wall biology in nature, in particular its role in environmental adaptation and signalling. Moreover, this research might lead to the discovery of new metabolic and regulatory pathways with great potential in the development of new species-specific antimicrobials therapies.

Group members

Laura Alvarez
Emilio Bueno
Tom Guest
Clara Lambert
Marta Nieckarz
Diego Rey
Gabriel Torrens
Christine Wegler

PhD students:
Barbara Ritzl.
Victor Pinedo.
Michael Gilmore.

Last updated: 2023-03-23

Content Responsible: Hampus Persson(hampus.persson@scilifelab.uu.se)