Hans Blom

Head of Unit: Integrated Microscopy Technologies, KTH

Key Publications
Revised diffusion law permits quantitative nanoscale characterization of membrane organization
2024
Three-Dimensional Super-Resolved Imaging of Paraffin-Embedded Kidney Samples
Kidney360, 2022
Super-resolution microscopy reveals that Na+/K+-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad
Cell Death & Disease, 2021

Research Interest

My research interest concerns technical development and application of fluorescence super-resolution imaging with a focus on precision medicine. Since 2015 the drive has been to optically image kidney morphology across scales, allowing for improved evaluation and understanding of renal pathophysiology. The long term goal is to enhance clinical diagnostic support and possible treatment strategies. In 2023 our group founded a spin-off company helping pharmaceutical kidney drug development by 3D nanoscale precision pathology (https://magnephy.com/).

  

Left: Glomeruli and renal tubule structures [Podocin – green; E-cadherin – magenta] 
Middle: Glomerular filtration unit with podocyte foot processes [Podocin – green].
Right: Cross-view of glomerular filtration barrier [Podocin – green; Collagen IV – magenta]  


  

Project members & collaborators

  • David Unnersjö-Jess (KTH/University of Cologne) – Postdoc
  • Robin Ebbestad (KI/DS) – Clinical PhD-student
  • Annika Östman Wernerson (KI) – National renal expert
  • Hannes Olauson (KI/KS) – National renal expert
  • Sigrid Lundberg (DS/KI ) – National renal expert
  • Thomas Benzig (NephroLab Cologne, Germany) – International renal expert
  • Jan Schmidt-Mende, Expert clinical pathology

Contact

hblom@kth.se

Last updated: 2024-11-29

Content Responsible: David Gotthold(david.gotthold@scilifelab.se)

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