Hans Blom

Head of Unit: Integrated Microscopy Technologies, KTH

Keywords
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Key publications

Super-resolution stimulated emission depletion imaging of slit diaphragm proteins in optically cleared kidney tissue.
Kidney International 89(1), 243-247 (2016).
doi.org/10.1038/ki.2015.308

Confocal super-resolution imaging of the glomerular filtration barrier enabled by tissue expansion.
Kidney international 93(4), 1008-1013 (2018).
doi.org/10.1016/j.kint.2017.09.019

A molecular mechanism explaining albuminuria in kidney disease.
Nature Metabolism 2, 461-474 (2020).
doi.org/10.1038/s42255-020-0204-y

A Fast and Simple Clearing and Swelling Protocol for 3D In-Situ Imaging of the Kidney across Scales.
Kidney International 99(4), 1010-1020 (2021).
doi.org/10.1016/j.kint.2020.10.039

Three Dimensional Super Resolved Imaging of Paraffin Embedded Kidney Samples.
Kidney360 3(3), 446–454 (2022).
doi.org/10.34067/KID.0005882021

Deep learning–based segmentation and quantification of podocyte foot process morphology suggests differential patterns of foot process effacement across kidney pathologies.
Kidney International 103(6), 1120-1130(2023)
doi.org/10.1016/j.kint.2023.03.0

SciLifeLab / Contact / Hans Blom

Research Interest

My research interest concerns technical development and application of fluorescence super-resolution imaging with a focus on precision medicine. Since 2015 the drive has been to optically image kidney morphology across scales, allowing for improved evaluation and understanding of renal pathophysiology. The long term goal is to enhance clinical diagnostic support and possible treatment strategies. In 2023 our group founded a spin-off company helping pharmaceutical kidney drug development by 3D nanoscale precision pathology (https://magnephy.com/).

  

Left: Glomeruli and renal tubule structures [Podocin – green; E-cadherin – magenta] 
Middle: Glomerular filtration unit with podocyte foot processes [Podocin – green].
Right: Cross-view of glomerular filtration barrier [Podocin – green; Collagen IV – magenta]  


  

Project members & collaborators

  • David Unnersjö-Jess (KTH/University of Cologne) – Postdoc
  • Robin Ebbestad (KI/DS) – Clinical PhD-student
  • Annika Östman Wernerson (KI) – National renal expert
  • Hannes Olauson (KI/KS) – National renal expert
  • Sigrid Lundberg (DS/KI ) – National renal expert
  • Thomas Benzig (NephroLab Cologne, Germany) – International renal expert
  • Jan Schmidt-Mende, Expert clinical pathology

Contact

hblom@kth.se

Last updated: 2024-11-29

Content Responsible: David Gotthold(david.gotthold@scilifelab.se)