Iskra Pollak Dorocic

Key publications

Characterization of transgenic mouse models targeting neuromodulatory systems reveals anatomical and functional heterogeneity of the dorsal raphe nucleus.
Cardozo Pinto DF, Yang H, Pollak Dorocic I, deJong JW, Han VJ, Peck JR, Liu C, Zhu Y, Beier KB, Smidt MP, Lammel S.
Nature Communications. 2019 Oct 11;10(1):4633.

A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse.
Ährlund-Richter S, Xuan Y, van Lunteren JA, Kim H, Ortiz C, Pollak Dorocic I, Meletis K, Carlén M.
Nature Neuroscience. 2019 Apr; 22(4):657-668.

A neural circuit mechanism for encoding aversive stimuli in the mesolimbic dopamine system.
de Jong JW, Afjei SA, Pollak Dorocic I, Peck JR, Liu C, Kim CK, Tian L, Deisseroth K, Lammel S.
Neuron. 2019 Jan 2; 101(1):133-151.

A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei.
Pollak Dorocic I, Fürth D, Xuan Y, Johansson Y, Pozzi L, Silberberg G, Carlén M, Meletis K.
Neuron. 2014 Aug 6; 83(3):663-78.  

Target selectivity of feedforward inhibition by striatal fast-spiking interneurons.
Szydlowski SN*, Pollak Dorocic I*, Planert H*, Carlén M, Meletis K, Silberberg G.
Journal of Neuroscience. 2013 Jan 23 ;33(4):1678-83

Research Interests

The immense complexity and computational power of the brain emerges from its vast connectivity and combination of cell types. We study the diversity of neuromodulatory neurons and circuits in the brain. By using a combination of molecular and system neuroscience tools to visualize, record and manipulate neural populations, we aim to understand their function and contribution to behavior.

Serotonin and dopamine are two of the main neuromodulators in the brain. The function of these neurons underlies healthy behavior, including motivation, exploration and social behaviors, while imbalances in these circuits are linked to neuropsychiatric illnesses, such as depression and anxiety.We utilize genetic and molecular profiling, neuroanatomy and connectivity mapping, in vivo imaging of neural activity, and optical neuromanipulation techniques to untangle very specific components of neural circuits, and study their contribution to both healthy brain function and disease.

Group members

Ana Rita Costa, Postdoc
Joseph Clerke, Postdoc
Charlotta Henningson, PhD student

Last updated: 2022-11-30

Content Responsible: David Gotthold(