Professor in Clinically Applied Proteomics
School of Biotechnology, KTH Royal Institute of Technology
Consultant in Hematology and Internal Medicine
Karolinska University Hospital Solna
Our group has three main interconnected areas of interest. Firstly, we use high throughput proteomic approaches to study the protein composition of blood plasma from patients with cardiovascular and thromboembolic disorders. We can then compare these ‘proteome profiles’ to those found in healthy controls, allowing us to identify novel protein biomarkers. Ultimately, the aim of this work is to develop tests that will allow for early identification of patients with sub-clinical disease and efficient diagnosis of those presenting with symptoms that could be indicative of a cardiovascular event, or to predict treatment response. Secondly, we are interested in the study of genetic susceptibility to cardiovascular disease and venous thromboembolism, especially gene regulatory mechanisms and how genetic variation can affect protein expression. Thirdly, we are specifically interested in the role of endothelial cell function in cardiovascular and thromboembolic disorders. Recently, we have in a collaboration led by Dr Lynn Butler, MMK, Karolinska Institutet, characterised the ‘endothelial specific transcriptome’, (Butler et al, Cell Systems. 2016 Sep 28;3(3)) which has allowed us to identify novel endothelial enriched genes. When combined with our genetic susceptibility testing, we can predict which of these endothelial specific genes could have an effect in our pathologies of interest. Thus, this provides us with a base for further investigation of the identified gene and its modulation and consequences in a specific context/patient cohort. To do this, data from in vitro molecular and functional studies on primary endothelial cells are combined with examination of patient material.
Maria Jesus Iglesias, Researcher
Laura Sanchez Rivera, Post doc
Maria Bruzelius, Post Doc
Philip Dusart, Postdoc (shared with Dr Lynn Butler, MMK/KI)
Leonardo Gottlob, Post doc (shared with Dr Lynn Butler, MMK/KI)
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