Jiri Bartek

Karolinska Institutet

Key publications

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen E, et al. Nat. Cell Biol. 2016 Jul;18(7):777-89

Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.Chroma K, Mistrik M, Moudry P, Gursky J, Liptay M, Strauss R, et al. Oncogene 2016 Nov;():

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. Moudry P, Watanabe K, Wolanin K, Bartkova J, Wassing I, Watanabe S, et al. J. Cell Biol. 2016 Feb;212(3):281-8

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer. Dietlein F, Kalb B, Jokic M, Noll E, Strong A, Tharun L, et al Cell 2015 Jul;162(1):146-59

Jiri Bartek

Research Interests

Research in the Bartek lab focuses on various mechanistic aspects of the DDR and DNA repair pathways. Of particular interest is discovery of targets and markers for personalized cancer treatment and finding novel components or mechanisms of genome integrity maintenance. Another of our long-term goals is to further unravel the principles of ribosome biogenesis surveillance and to understand the dynamics and the finer details of the p53 pathway in sensing ribosome dysfunction, and how ribosomal stress crosstalk with the DNA damage response.

Group members

Jiri Bartek, Professor
Jirina Bartkova, Senior researcher
Jaime Andrés Espinoza Ruiz, Researcher
Johana Fernandez Martinez, Laboratory technician
Dimitris Kanellis, Project leader
Mikael Lindström, Senior researcher
Per Moberg, Research coordinator
Asimina Zisi, PhD student
Ewelina Dratkiewicz, PostDoc
Martin Kosar, PostDoc
Anne-Sofie Nilsson, Biomedical scientist


Andrea Björk, postdoctoral researcher, 2016-2021
Terezie Imrachova, visiting researcher, 2021
Athina Eleftheraki, master student, 2021
Karla Paola Leal Villegas, visiting PhD student, 2021
Gábor Merényi, research assistant, 2019-2021
Sidorela Selami, research assistant, 2020
Kenneth Schou, postdoctoral researcher, 2017-2020
Fenne Van Dongen, master student, 2019
Anastasios Mastroanastasiou, undergraduate summer intern, 2018
Kaveh Moazemi-Goudarzi, PhD student, 2015-2018
Annika Ranta, undergraduate summer intern, 2017
Alexandros Iskantar, undergraduate student Erasmus+, 2017

Last updated: 2023-11-30

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