Karin Forsberg Nilsson

Key publications

Roy A, Sakthikumar S, Kozyrev SV, Nordin J, Pensch R, Mäkeläinen S, Pettersson M; Zoonomia Consortium; Karlsson EK, Lindblad-Toh K, Forsberg-Nilsson K.
Using evolutionary constraint to define novel candidate driver genes in medulloblastoma
Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2300984120. doi: 10.1073/pnas.2300984120. 
Epub 2023 Aug 7.

Sullivan, P., Meadows, J., Gazal, S., Phan, B., Li, X., Genereux, D., Dong, M., Bianchi, M., Andrews, G., Sakthikumar, S., Nordin, J., Roy, A., Christmas, M., Manrinescu, V., Wang, C., Wallerman, O., Xue, J., Li, Y., Yao, S., Sun, C., Szatkiewicz, J., Wen, J., Huckins, L., Lawler, A., Keough, K., Zheng, Z., Zeng, J., Wray, N., Li, Y., Johnson, J., Chen, J., Zoonomia Consortium, Paten, B., Reilly, S., Hughes, G., Weng, Z., Pollard, K., Pfenning, A., Forsberg-Nilsson, K., Karlsson, E., Lindblad-Toh, K.
Leveraging Base Pair Mammalian Constraint to Understand Genetic Variation and Human Disease.
Science, 2023, Apr 28;380 (6643):eabn2937. doi: 10.1126/science.abn2937.

Peglion F, Capuana L, Perfettini I, Boucontet L, Braithwaite B, Colucci-Guyon E, Quissac E, Forsberg-Nilsson K, Llense F, Etienne-Manneville S.
PTEN inhibits AMPK to control collective migration.
Nat. Commun., 2022, Aug 11;13(1):4528. doi: 10.1038/s41467-022-31842-y.

Governa, V., Talbot, H., Goncalves de Oliviera, K., Cerezo-Magaña, M., Bång-Rudenstam, A., Johansson, M., Månsson, A-S., Forsberg-Nilsson, K., Marko-Varga, G., Perez, J.E., Darabi, A., Malmström, J., Bengzon, J., Welinder, C, and Belting, M.,
Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization.
Proc. Natl. Acad. Sci., 2022 Vol. 119 No. 9 e2114456119

Sakthikumar, S., Roy, A., Haseeb, L., Pettersson, M., Sundström, E., Marinescu, V., Lindblad-Toh., K. and Forsberg-Nilsson, K.
Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.
Genome Biology, 2020, Jun 9;21(1):127. doi: 10.1186/s13059-020-02035-x

Jimenez-Pascual, A., Hale, J., Kordowski, A., Pugh J., Silver, D. Bayik, D., Roversi, G., Alban, T., Rao, S., Chen, R., McIntyre, T., Colombo, G., Taraboletti, G., Holmberg, K., Forsberg-Nilsson, K., Lathia, J., and Siebzehnrubl, F.
ADAMDEC1 maintains a novel growth factor signaling loop in cancer stem cells.
Cancer Discovery, 2019 Aug 21. pii: CD-18-1308. doi: 10.1158/2159-8290.CD-18-1308.

Karin Forsberg Nilsson

The goal of my research is to improve therapy for malignant brain tumors, such as glioblastoma (GBM) and medulloblastoma (MB). GBM is a molecularly heterogeneous and highly aggressive brain tumor, with one of the worst five-year survival rates of all human cancers. Curative therapy for MB, which mainly affects children is better, but for many patients the outcome is still poor.

We have two lines of research. In the first project, we decipher non-coding regulatory regions of cancer genomes to define new candidate genes in brain tumors. Here, we harness a cornerstone of human biology, namely that evolutionary conservation implies function, and use this concept to identify non-coding mutations with regulatory potential. We have shown that mutations in evolutionary constraint positions are functional, and can suggest drug targets in brain tumors.

Secondly, we target the invasive niche, since brain tumors can sculpt the extracellular matrix (ECM) to support cancer progression. Proteoglycans are important components of the brain ECM, and we have shown that their remodeling is part of the malignant brain tumor signature. Current projects therefore aim to target molecules in the proteoglycan biosynthesis or degradation pathways.

My laboratory is situated in the interdisciplinary environment at the Rudbeck Laboratory with close clinical interactions with Uppsala University Hospital.

Group Members

Grzegorz Wicher, docent, researcher
Ananya Roy, Dr, researcher
Lulu Haseeb, MD PhD student
Mattias Belting, visiting professor
Monica Nistér, Professor emerita
Lukas Peltzer, Master’s student

Last updated: 2023-11-30

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