I study molecular mechanisms of positive-sense RNA virus replication. In this work, my group resides at the intersection of molecular virology, structural biology and membrane trafficking. Our research often has a strong component of cryo-EM, in particular cryo-electron tomography of cells and tissues. In this work, we rely heavily on Umeå Centre for Electron Micrsocopy, a SciLifeLab national facility for cryo-EM.
Lars-Anders Carlson
Umeå University
Keywords
Key Publications
Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in <i>Giardia intestinalis</i>
Nucleic Acids Research, 2024
Structural basis for lipid transfer by the ATG2A-ATG9A complex.
Nature structural & molecular biology, 2024
In vitro reconstitution reveals membrane clustering and RNA recruitment by the enteroviral AAA+ ATPase 2C.
PLoS pathogens, 2024
A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Ultrastructural insights into the microsporidian infection apparatus reveal the kinetics and morphological transitions of polar tube and cargo during host cell invasion.
PLoS biology, 2024