Leif Andersson

Key publications
Van Laere,A.S., Nguyen,M., Braunschweig,M., Nezer,C., Collette,C., Moreau,L., Archibald,A., Haley,C.S., Buys,N., Tally,M., Andersson,G., Georges,M. and Andersson,L. 2003.
A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig.
Nature 425:832-836. 2003.

Andersson LS, Larhammar M, Memic F, Wootz H, Schwochow D, Rubin CJ, Patra K, Arnason T, Wellbring L, Hjälm G, Imsland F, Petersen JL, McCue ME, Mickelson JR, Cothran G, Ahituv N, Roepstorff L, Mikko S, Vallstedt A, Lindgren G, Andersson,L*, Kullander K. 
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice.
Nature 488:642-646. 2012.

Lamichhaney S, Berglund J, Sällman Almén M, Maqbool K, Grabherr M, Martinez-Barrio A, Promerová M, Rubin C-J, Wang C, Zamani N, Grant BR, Grant PR, Webster MT, Andersson L.
Evolution of Darwin’s finches and their beaks revealed by genome sequencing.
Nature 518:371-375. 2015.

Lamichhaney S, Fan G, Widemo F, Gunnarsson U, Thalmann DS, Hoeppner MP, Kerje S, Gustafson U, Shi C, Zhang H, Chen W, Liang X, Huang L, Wang J, Liang E, Wu Q, Lee SM, Xu X, Höglund J, Liu X, Andersson L.
Structural genomic changes underlie alternative reproductive strategies in the ruff (Philomachus pugnax).
Nature Genetics 48:84-88. 2016.

Han F, Jamsandekar M, Pettersson ME, Su L, Fuentes-Pardo AP, Davis BW, Bekkevold D, Berg F, Casini M, Dahle G, Farrell ED, Folkvord A, Andersson L. 
Ecological adaptation in Atlantic herring is associated with large shifts in allele frequencies at hundreds of loci.
eLife 9:e61076. 2020.

Enbody ED, Sendell-Price AT, Sprehn CG, Rubin C-J, Visscher P, Grant BR, Grant PR, Andersson L.
Community-wide genome sequencing reveals 30 years of Darwin’s finch evolution.
Science 381: adf6218. 2023.

Leif Andersson

The work is my group aims to advance knowledge concerning the relationship between genetic and phenotypic variation. We are carrying out comparative genomics using domestic animals as well as various natural populations as models for phenotypic evolution. This has resulted in discoveries of genotype-phenotype relationships such as mutations affecting pigmentation across domestic animals, gaits in horses, comb morphology in chickens, muscle growth in pigs and the genetics of domestication. Much of the current research program is focusing on natural populations including for instance the evolution of Darwin’s finches and their beaks, a supergene controlling male mating strategies in the ruff and the genetic basis for ecological adaptation in Atlantic herring and other fish species. The work on Atlantic herring, one of the most abundant vertebrates on earth, has revealed an unprecedented resolution in detecting genes
contributing to ecological adaption. This is illustrated in the attached figure showing that a missense mutation (Phe261Tyr) in the rhodopsin gene has contributed to the adaptation to the red-shifted light environment in the Baltic Sea.

Group Members

Arianna Cocco
Ryan Daniels
Sabine Felkel
Mafalda Ferreira
Jake Goodall
Mårten Larsson
Cheng Ma
Mats Pettersson
Fahime Sangdehi
Matteo Sebastianelli
Dandan Wang
Leyi Su

Last updated: 2023-12-04

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