We study the underpinings of glioma development and glioma treatment resistance with focus on the cell of origin and cancer stem cells. The aim is to uncover novel pathways and targets to which drugs can be identified or developed. We use a number of validated mouse models in which the cell of origin can be defined, and a large repository of patient-derived human glioblastoma cell cultures (HGCC) established under stem cell conditions. By cross-species bioinformatics analyses we compare gene expression data from mouse and human glioma to identify candidate glioma genes that are further analysed for their relevance as functional biomarkers. Our long-term goal is to provide a better patient stratification and more efficient treatment strategies for each group of patients.
Ida Gustavsson, M.Sc., Research assistant
Prathyusha Maturi, M.Sc., PhD student
Anders Sundström, M.Sc., Research engineer
Yuan Xie, PhD, postdoc