I am a new Faculty at Uppsala University. I study fundamental molecular mechanisms of life, by determining structure-functional and evolutionary relationships in large non-coding RNAs involved in transcription regulation. Our studies provide near-atomic insights into vital biological pathways such as splicing and cell cycle regulation. A key focus is to use this information for translational purposes, by developing RNA-directed drugs and by using RNA as a therapeutic molecule.
Marco Marcia
Uppsala University
Key Publications
The multiple molecular dimensions of long noncoding RNAs that regulate gene expression and tumorigenesis.
Current opinion in oncology, 2022
Computer-aided design of RNA-targeted small molecules: A growing need in drug discovery
Chem, 2021
Noncoding RNAs: biology and applications-a Keystone Symposia report.
Annals of the New York Academy of Sciences, 2021
Screening strategies for identifying RNA- and ribonucleoprotein-targeted compounds
Trends in Pharmacological Sciences, 2021
Finding the Ion in the RNA-Stack: Can Computational Models Accurately Predict Key Functional Elements in Large Macromolecular Complexes?
Journal of Chemical Information and Modeling, 2021