Maria Pernemalm

Karolinska Institutet

Keywords
Key publications

Eric W. Deutsch, Gilbert S. Omenn, Zhi Sun, Michal Maes, Maria Pernemalm, Krishnan K.

Palaniappan, Natasha Letunica, Yves Vandenbrouck, Virginie Brun, Sheng-ce Tao, Xiaobo Yu, Philipp

  1. Geyer, Vera Ignjatovic, Robert L. Moritz, and Jochen M. Schwenk. Advances and Utility of the

Human Plasma Proteome. J. Proteome Res. 2021, XXXX, XXX, XXX-XXX. Publication Date: October 21,

2021 doi:10.1021/acs.jproteome.1c00657. https://pubmed.ncbi.nlm.nih.gov/34672606/

 

Veerman RE, Teeuwen L, Czarnewski P, Güclüler Akpinar G, Sandberg A, Cao X, Pernemalm M, Orre LM, Gabrielsson S, Eldh M. Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin.

J Extracell Vesicles. 2021 Jul;10(9):e12128. doi: 10.1002/jev2.12128. Epub 2021 Jul 22.

PMID: 34322205

 

Cao X, Sandberg A, Araújo JE, Cvetkovski F, Berglund E, Eriksson LE, Pernemalm M. Evaluation of Spin Columns for Human Plasma Depletion to Facilitate MS-Based Proteomics Analysis of Plasma.

J Proteome Res. 2021 Jul 28. doi: 10.1021/acs.jproteome.1c00378. Online ahead of print.

PMID: 34320313

 

Babačić H, Eriksson H, Pernemalm M. Plasma proteome alterations by MAPK inhibitors in BRAFV600-mutated metastatic cutaneous melanoma. Neoplasia. 2021 Aug;23(8):783-791. doi: 10.1016/j.neo.2021.06.002. Epub 2021 Jul 8. PMID: 34246984

 

Terkelsen T, Pernemalm M, Gromov P, Børresen-Dale AL, Krogh A, Haakensen VD, Lethiö J, Papaleo E, Gromova I. High throughput proteomics of breast cancer interstitial fluid: identification of tumor subtype-specific serologically relevant biomarkers. Mol Oncol. 2021 Feb;15(2):429-461.

 

Babačić H, Lehtiö J, Pico de Coaña Y, Pernemalm M*, Eriksson H*

In-depth plasma proteomics reveals increase in circulating PD-1 during anti-PD-1 immunotherapy in patients with metastatic cutaneous melanoma. J Immunother Cancer. 2020 May;8(1):e000204. doi: 10.1136/jitc-2019-000204.PMID: 32457125 *Shared last authorship

 

Levitsky A, Pernemalm M, Bernhardson BM, Forshed J, Kölbeck K, Olin M, Henriksson R, Lehtiö J, Tishelman C, Eriksson LE. Early symptoms and sensations as predictors of lung cancer: a machine learning multivariate model. Sci Rep. 2019 Nov 11;9(1):16504. doi: 10.1038/s41598-019-52915-x.

 

Ezzat K, Pernemalm M,  Pålsson M, Roberts TC, Järver P, Dondalska A, Bestas B, Sobkowiak MJ, Levänen B, Sköld M, Thompson EA, Saher O, Kari OK, Lajunen T, Sverremark Ekström E, Nilsson C, Ishchenko Y, Malm T, Wood MJA, Power UF, Masich S, Lindén A, Sandberg JK, Lehtiö J, Spetz A-L, EL Andaloussi S. The Viral Protein Corona Directs Viral Pathogenesis and Amyloid Aggregation. Nat Commun. 2019 May 27;10(1):2331. doi: 10.1038/s41467-019-10192-2.PMID: 31133680

 

Pernemalm M, Sandberg A, Zhu Y, Boekel J, Tamburro D, Schwenk J M, Björk A, Wahren-Herlenius M, Åmark H, Östenson C.G, Westgren M, Lehtiö J. In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta. eLife 2019 Apr 8;8

 

Indira Chandran V,  Welinder C,  Månsson AS,  Offer S,  Freyhult E,  Pernemalm M,  Lund SM,  Pedersen S,  Lehtiö J,  Marko-Varga G,  Johansson MC,  Englund E,  Sundgren PC,  Belting M. Ultrasensitive Immunoprofiling of Plasma Extracellular Vesicles Identifies Syndecan-1 as a Potential Tool for Minimally Invasive Diagnosis of Glioma. Clinical cancer research: an official journal of the American Association for Cancer Research 2019 Jan 24

Maria Pernemalm

Research interests

The major focus of my research is method development to expand and improve the concept of mass spectrometry based proteomics analysis of biological fluids in health and disease.

The plasma team works both on method development and applied projects involving expanded applications of plasma proteome analysis such as plasma protein interaction with viruses and nanoparticles, proteogenomics biomarker discovery, and approaches to combine biochemical plasma markers with symptoms clusters for improved accuracy and sensitivity in precision medicine.

Group members

  • Haris Babacic (PhD Student)
  • Noora Sissala (PhD Student)
  • Nidhi Sharma (Post doc)

Contact

Email

Maria.pernemalm@scilifelab.se

Visiting address

SciLifeLab, Tomtebodavägen 23A, 17121 Solna

Postal address K7 Onkologi-Patologi, K7 Forskning Lehtiö, 171 77 Stockholm

Last updated: 2022-11-30

Content Responsible: David Gotthold(david.gotthold@scilifelab.se)