Novel cancer-targeting strategies for improved molecular radiotherapy
Molecular radiotherapy has revolutionised the treatment of several malignancies in recent years. However, treatment of solid tumours has been hampered by dose-limiting toxicities and tumour radioresistance.
The aim of our research is to develop novel radiolabelled cancer targeting agents and radio-sensitisation strategies for improved molecular cancer diagnostics and therapy. To enable this, targeting molecules towards cancer-associated targets are generated, radiolabelled and further evaluated and developed for use in precision imaging, theranostics, and molecular radiotherapy. Moreover, novel strategies to potentiate therapeutic effects of radiotherapy
Ultimately, our cancer targeting radiopharmaceuticals could be clinically applied to non-invasively characterise and image cancer cells, stratify patients, monitor treatment response, as well as for molecular radiotherapy. Moreover, radio-sensitisation strategies may be applied to improve outcomes of radiotherapy, enabling more effective radiation treatments, potentially also reducing radiation exposure and undesirable side effects in normal tissues.
In time, we hope that our research will contribute to improving radiotherapy treatment outcomes and prolong cancer patient survival.
- Marika Nestor, Group Leader
- Saloni Chopra, PhD student
- Hanna Berglund, PhD student
- Tabassom Mohajershojai, PhD student
- Preeti Jha, Postdoctor
- Anja Lundgren Mortensen, visiting researcher
- Hanna Yushchyshyna, visiting researcher