Mario Ruiz

Head of Unit: Oligonova (Biology), University of Gothenburg

Key publications

Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and embryogenesis.
Ruiz M, Devkota R, Panagaki D, Bergh PO, Kaper D, Henricsson M, Nik A, Petkevicius K, Höög JL, Bohlooly-Y M, Carlsson P, Borén J, Pilon M.
Nat Commun. 2022 Nov 22;13(1):7162.

Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.
Zhang J, Ruiz M, Bergh PO, Henricsson M, Stojanović N, Devkota R, Henn M, Bohlooly-Y M, Hernández-Hernández A, Alsheimer M, Borén J, Pilon M, Shibuya H.
Nat Commun. 2024 Mar 14;15(1):2315.

AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin.
Ruiz M, Ståhlman M, Borén J, Pilon M.
J Lipid Res. 2019 May;60(5):995-1004. doi: 10.1194/jlr.M092494.

Mission

As part of the Drug Discovery & Development – DDD – platform, OligoNova Biology offer industry-standard infrastructure, expertise, and strategic support to translate fundamental research findings into patient-benefitting therapeutic oligonucleotide molecules. We do this in collaboration with OligoNova Chemistry and the other facilities at SciLifeLab DDD and Swedish academic groups. 

Our expertise goes from bioinformatics to cell-based-assays and supporting in-vivo studies. From high-throughput screens and “omics” to deep characterization and phenotyping.

Besides, our main “full-drug-discovery project”, our unit is engaged in research and development of new methods. We offer consultancy and access to state-of-the-art instrumentation to academics and biotech/pharma companies – “service projects” -.

We are always open to innovations & new technologies and look forward to collaborate with you and support your basic and translational scientific research and the development of the drugs of the future.

Group Members:

Cell Biology:

– Monika Vilares
– Emelie Vilhelmsson Wesén
– Ranjan Devkota

Bioinformatics:

– Sanna Abrahamsson
– Subazini Thankaswamy Kosalai
– Alina Orozco

Last updated: 2025-01-17

Content Responsible: Hampus Persson(hampus.persson@scilifelab.uu.se)