We study how protein structure relates to function. Our research focuses on obtaining structural information of protein radicals and high-valent metal sites for challenging chemical reactions. This is crucial for designing novel biomimetic catalysts for green chemistry and energy conversion. In particular we study ribonucleotide reduction and biochemical energy and gas metabolism. The research is methods-centered and we employ synchrotron and free-electron laser X-ray crystallography, Cryo-EM, MicroED, protein design, enzymatic assays, and various spectroscopic techniques.
