Building a live-cell microscopy-compatible platform for 3D cell cultures, spheroids, micro-tissue and organoid research using ultrasonic radiation forces as a physical force field to assemble cells in 3D in a highly controllable manner. The goal is to use the platform for various in-vitro applications within microtissue and micro-tumor research.
Martin Wiklund
Key Publications
Björn Hammarström, Karl Olofsson, Valentina Carannante, Sarah Alberio, Patrick A Sandoz, Björn Önfelt & Martin Wiklund (2025). “Adaptive ultrasonic actuation for dynamic formation and characterization of 3D cell cultures”. Sensors and Actuators B: Chemical. https://doi.org/10.1016/j.snb.2024.137173
Martim Costa, Björn Hammarstrom, Liselotte van der Geer, Selim Tanriverdi, Haakan N Joensson, Martin Wiklund, Aman Russom (2024). “EchoGrid: High-Throughput Acoustic Trapping for Enrichment of Environmental Microplastics”. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.4c00933
Björn Hammarström, Thomas J Lane, Hazal Batili, Raymond Sierra, Martin Wiklund & Jonas A Sellberg (2022). “Acoustic Focusing of Protein Crystals for In-Line Monitoring and Up-Concentration during Serial Crystallography”. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.2c01701
Niklas Sandström, Valentina Carannante, Karl Olofsson, Patrick A. Sandoz, Elisabeth L. Moussaud-Lamodière, Brinton Seashore-Ludlow, Hanna Van Ooijen, Quentin Verron, Thomas Frisk, Madoka Takai, Martin Wiklund, Päivi Östling & Björn Önfelt (2022). “Miniaturized and multiplexed high-content screening of drug and immune sensitivity in a multichambered microwell chip”. Cell Reports Methods. https://doi.org/10.1016/j.crmeth.2022.100256
Joseph Rufo, Feiyan Cai, James Friend, Martin Wiklund & Tony Jun Huang (2022). “Acoustofluidics for biomedical applications”. Nature Reviews Methods Primers. https://par.nsf.gov/servlets/purl/10391293
Karl Olofsson, Björn Hammarström & Martin Wiklund (2020). “Acoustic separation of living and dead cells using high density medium”. Lab on a chip. https://doi.org/10.1039/D0LC00175A