Key publications

B. Mitran*, Z. Varasteh*, U. Rosenström, R. K. Selvaraju, G. Lindeberg, J. Sörensen, M. Larhed, V. Tolmachev, A. Orlova: Selection of Optimal Chelator Improves the Contrast of GRPR Imaging Using Bombesin Analogue RM26. Int. J. Oncol. 48 (2016), 2124-2134. DOI: org/10.3892/ijo.2016.3429

K. Engen, U. Rosenström, H. Axelsson, V. Konda, L. Dahllund, M. Otrocka, K. Sigmundsson, A. Nikolaou, G. Vauquelin, M. Hallberg, A. Jenmalm Jensen, T. Lundbäck*, M. Larhed*: Identification of drug-like inhibitors of insulin-regulated aminopeptidase through small molecule screening. Assay Drug Dev. Technol. 14 (2016), 180-193. DOI: 10.1089/adt.2016.708

M. Larhed, M. Hallberg, A. Hallberg: Nonpeptide AT2 Receptor Agonists. Med. Chem. Rev. 51 (2016), 69-82.

S. Diwakarla, E. Nylander, A. Grönbladh, S. R. Vanga, Y. S. Khan, H. Gutiérrez-de-Terán, J. Sävmarker, L. N. V. Pham, T. Lundbäck, A. Jenmalm Jensen, R. Svensson, P. Artursson, S. Zelleroth, K. Engen, U. Rosenström, M. Larhed, J. Åqvist, S. Y. Chai, M. Hallberg*: Aryl sulfonamide inhibitors of insulin-regulated aminopeptidase enhance spine density in primary hippocampal neuron cultures. ACS Chem. Neurosci. 7 (2016), 1383-1392. DOI: 10.1021/acschemneuro.6b00146

B. Skillinghaug, J. Rydfjord, J. Sävmarker, M. Larhed*: Microwave Heated Continuous Flow Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones. Org. Proc. Res. Dev. 20 (2016), 2005−2011. DOI: 10.1021/acs.oprd.6b00306

Research interests

I have developed a number of synthesis methods that are among the most frequently used for fast synthesis of drug molecules, including the MW-assisted Suzuki coupling and the oxidative Heck reaction. My main research interests are: I) design and synthesis of new enzyme inhibitors and peptidomimetics for treatment of HIV, hepatitis C, TB, cognitive disorders, pain and inflammatory conditions, II) development of new and rapid synthesis strategies, including microwave-assisted palladium-catalyzed methods of importance for organic- and medicinal chemistry, III) flow methodologies for rapid scale-up (scale-out) and environmentally benign organic synthesis, and IV) design and synthesis of novel PET and PET/MR radiotracers.

Bibliometric data 2014-05-28: >170 publications, h-index = 45 (Google Scholar), 41 (Web of Science), five approved patents (all sold), faculty opponent 11 times. Invited speaker as plenary or invited lecturer at >30 international congresses and symposia.

Group members

Dr Tamal Roy, Post doc
Dr Jayendra Patel, Post doc
Dr Bobo Skillinghaug, Researcher
Dr Jonas Sävmarker, Researcher
Karin Engen, PhD student
Ahmed Adeyemi, PhD student
Sara Bergman, PhD student
Rebecka Isaksson, PhD student
Jonas Rydfjord, PhD student
Linda Åkerbladh, PhD student

Contact

mats.larhed@orgfarm.uu.se

Last updated: 2022-11-30

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