Beyond the classical double-helix, DNA in our cells adopts unique four-stranded structures called G-quadruplexes (G4) and intercalated motifs (iM).G4s form in guanine-rich single-stranded DNA, while iMs emerge in their complementary region. My research goal is to understand the biological impact of quadruplex structures in health, disease and therapy, aiming to reach my long-term vision of drug discovery; the development of novel therapeutic strategies by targeting four-stranded DNA structures.
Nasim Sabouri
Umeå University
Key Publications
CRISPR-Cas9 targeting of G-Quadruplex DNA in ADH1 promoter highlights its role in transcriptome and metabolome regulation
Nucleic Acids Research, 2025
The proviral factor NUP153 binds viral proteins and RNA to modulate protein translation at viral amplification site early in flavivirus infection
2025
Photodynamic Therapy Using a Heavy-Atom-Free G-Quadruplex-Targeted Photosensitizer to Efficiently Regress Rhabdomyosarcoma Tumors In Vivo
ACS Pharmacology & Translational Science, 2025
Mechanistic Insights into Poly-(rC)-binding protein 1 driven Unfolding of Selected i-motif DNA at G1/S checkpoint
2025