Beyond the classical double-helix, DNA in our cells adopts unique four-stranded structures called G-quadruplexes (G4) and intercalated motifs (iM).G4s form in guanine-rich single-stranded DNA, while iMs emerge in their complementary region. My research goal is to understand the biological impact of quadruplex structures in health, disease and therapy, aiming to reach my long-term vision of drug discovery; the development of novel therapeutic strategies by targeting four-stranded DNA structures.
Nasim Sabouri
Umeå University
Key Publications
Complete de novo assembly of yeast genomes using enzyme-free, dense optical genome mapping
2026
Proviral NUP153 binding to viral proteins and RNA regulates structural–nonstructural protein ratios in orthoflavivirus infection
Nature Communications, 2026
Mechanistic insights into PCBP1-driven unfolding of selected i-motif DNA at G1/S checkpoint
Nature Communications, 2026
Evidence for a functional interaction between yeast Pol ε and PCNA in vivo
Nucleic Acids Research, 2025
CRISPR-Cas9 targeting of G-Quadruplex DNA in ADH1 promoter highlights its role in transcriptome and metabolome regulation
Nucleic Acids Research, 2025