Beyond the classical double-helix, DNA in our cells adopts unique four-stranded structures called G-quadruplexes (G4) and intercalated motifs (iM).G4s form in guanine-rich single-stranded DNA, while iMs emerge in their complementary region. My research goal is to understand the biological impact of quadruplex structures in health, disease and therapy, aiming to reach my long-term vision of drug discovery; the development of novel therapeutic strategies by targeting four-stranded DNA structures.
Nasim Sabouri
Umeå University
Key Publications
Mechanistic Insights into Poly-(rC)-binding protein 1 driven Unfolding of Selected i-motif DNA at G1/S checkpoint
2025
Photodynamic Therapy Using a Heavy-Atom-Free G-Quadruplex-Targeted Photosensitizer to Efficiently Regress Rhabdomyosarcoma Tumors In Vivo
ACS Pharmacology & Translational Science, 2025
CRISPR-Cas9 Targeting of G-Quadruplex DNA in ADH1 promoter Highlights its role in Transcriptome and Metabolome Regulation
2025
Organelle-Specific Thiochromenocarbazole Imide Derivative as a Heavy-Atom-Free Type I Photosensitizer for Biomolecule-Triggered Image-Guided Photodynamic Therapy
The Journal of Physical Chemistry Letters, 2025
A Rationally Designed Azobenzene Photoswitch for DNA G‐Quadruplex Regulation in Live Cells
Angewandte Chemie International Edition, 2025