Ola Söderberg

Key publications

Söderberg O, Gullberg M, Jarvius M, Ridderstråle K, Leuchowius KJ, Jarvius J, Wester K, Hydbring P, Bahram F, Larsson LG & Landegren U
“Direct observation in situ of individual endogenous protein complexes by proximity ligation”
Nature Methods, 2006, 3(12): 995-1000

Clausson CM, Allalou A, Weibrecht I, Mahmoudi S, Farnebo M, Landegren U, Wählby C & Söderberg O
“Increasing the dynamic range of in situ PLA”
Nature Methods, 2011, 8(11): 892-893

Weibrecht I, Lundin E, Kiflemariam S, Mignardi M, Grundberg I, Larsson C, Koos B, Nilsson M & Söderberg O
“In situ detection of individual mRNA molecules and protein complexes or post-translational modifications using padlock probes combined with the in situ proximity ligation assay”
Nature Protocols, 2013, 8(2): 355-372

Leuchowius KJ, Clausson CM, Grannas K, Erbilgin Y, Botling J, Zieba A, Landegren U & Söderberg O
“Parallel visualization of multiple protein complexes in individual cells in tumor tissue”
Mol Cell Proteomics, 2013, 12(6): 1563-1571

Koos B, Cane G, Grannas K, Löf L, Arngården L, Heldin J, Clausson CM, Klaesson A, Hirvonen MK, Souza de Oliviera FM, Talibov V, Pham N, Auer M, Danielson H, Haybaeck J, Kamali-Moghaddam M & Söderberg O
“Proximity dependent initiation of hybridization chain reaction”
Nature Communications, 2015, 6, 7294

Raykova D, Kermpatsou D, Malmqvist T, Harrison PJ, Rubin Sander M, Stiller C, Heldin J, Leino M, Ricardo S, Klemm A, David L, Spjuth O, Vemuri K, Dimberg A, Sundqvist A, Norlin M, Klaesson A, Kampf C & Söderberg O
“A method for Boolean Analysis of Protein Interactions at a Molecular Level”
Nature Communications, 2022, 13(1):4755

Methods and technologies for cell analysis are a cornerstone in research and healthcare, facilitating researchers in answering questions about the origins and progression of disease, and helping clinicians to set a correct diagnosis. Over the last two decades we have mainly focused on the development of methods; such as in situ PLA, ProxHCR and MolBoolean; to provide the ability to monitor protein-protein interactions and post-translational modifications in fixed cells and tissues, which is essential for the studies and understanding of cellular signaling.

These methods use DNA as a reporter molecule and are based on natural occurring enzymes. Our current research explores the possibility to go beyond the boundaries of what nature can provide, to design enzymes that cannot be made through evolution. We have recently engineered a DNA-polymerase that isn´t compatible with life, that provides unique opportunities for development of novel methods for medical research.

Last updated: 2025-01-08

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