The Translational PET Imaging lab is applying in vivo molecular imaging techniques, e.g. Positron Emission Tomography (PET), for advancement of our understanding and management of different pathologies, in particular metabolic disease and cancer.
My current main research interests are:
I) non-invasive imaging methodologies for assessment of beta cell-mass in diabetes,
II) imaging markers for activated T-cells, for use in immuno-oncology and in the many diseases where inflammation is an important feature,
III) assisting drug development, by design of novel imaging-based endpoints (e.g. in vivo mode of action, drug biodistribution),
IV) translational research, i.e. bringing radiopharmaceuticals from design and radiolabeling, via preclinical evaluation, to clinical proof-of-concept.
Bibliometric data January 2020: >65 publications, h-index = 22. Invited speaker at >20 international congresses.
Olof Eriksson, Associate Senior Lecturer, SciLifeLab Fellow
Emmi Puuvuori, Ph.D. student
Maria Rosestedt, Postdoc
Bo Zhang, Postdoc
Pierre Cheung, Ph.D. student
Irina Velikyan, Researcher
Eriksson O, Irina Velikyan, Torsten Haack, Martin Bossart, Andreas Evers, Iina Laitinen, Philip Larsen, Oliver Plettenburg, Akihiro Takano, Christer Halldin, Gunnar Antoni, Lars Johansson, Stefan Pierrou, Michael Wagner. Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates. Sci Rep. 2019;9(1):14960.
Eriksson O, Johnström P, Cselenyi Z, Jahan M, Selvaraju RK, Jensen-Waern M, Sörhede-Winzell M, Halldin C, Skrtic S, Korsgren O. In vivo visualization of beta cells by targeting of GPR44. Diabetes. 2018;67:182-192.
Carlbom L, Espes D, Lubberink M, Martinell M, Johansson L, Ahlström H, Carlsson PO, Korsgren O, Eriksson O. [11C]5-hydroxy-tryptophan PET for assessment of islet mass during progression of type 2 diabetes. Diabetes. 2017;66:1286-1292.
Eriksson O, Mikkola K, Espes D, Tuominen L, Virtanen K, Forsbäck S, Haparanta-Solin M, Hietala J, Solin O, Nuutila P. The Cannabinoid Receptor-1 is an imaging biomarker of Brown Adipose Tissue. J Nucl Med. 2015;56:1937-41.
*Eich T, *Eriksson O, Lundgren T. Visualization of early engraftment in clinical islet transplantation by positron-emission tomography. N Engl J Med. 2007;356:2754-5.