Oommen Varghese

Uppsala University

Keywords
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Key Publications

S. Tavakoli, A. Kocatürkmen, O. P. Oommen, O. P. VARGHESE*, Ultra-fine 3D bioprinting of dynamic hyaluronic acid hydrogel for in vitro modelling, Adv. Mater., 2025, 2500315.

C. Leliopoulos, H. Mokhtari, S. Tavakoli, V. Shtender, C. Persson, O. P. VARGHESE*, Quantitative assessment of chemical modifications of macromolecules through counterion measurement, Chem. Mater., 2025, DOI: 10.1021/acs.chemmater.5c02871.

S. Tavakoli, N. Krishnan, H. Mokhtari, O. P. Oommen, O. P. VARGHESE*, Fine‐tuning dynamic cross–linking for enhanced 3D bioprinting of hyaluronic acid hydrogels, Adv. Funct. Mater., 2024, 34, 2307040.

S. Kadekar, G. N. Nawale, K. Karlsson, C. Ålander, O. P. Oommen, O. P. VARGHESE* Synthetic design of asymmetric miRNA with engineered 3′-overhang to improve strand selection. Mol. Ther. Nucleic Acids, 2019, 16, 597-604.

M. Paidikondala, V. K. Rangasami, G. N. Nawale, T. Casalini, G. Perale, S. Kadekar, G. Mohanty, T. Salminen, O. P. Oommen, O. P. VARGHESE*, An unexpected role of hyaluronic acid in trafficking siRNA across cellular barrier: The first biomimetic, anionic, non-viral transfection method. Angew. Chem. Int. Ed., 2019, 58, 2815 – 2819.

SciLifeLab / Contact / Oommen Varghese

Oommen Varghese

My research group focuses on the development of next-generation nucleic acid therapeutics for gene silencing, as well as advanced biomaterials for the delivery of small molecules, nucleic acid drugs, and therapeutic proteins. We combine these efforts with 3D bioprinting to create functional tissue models and scaffolds. Our work emphasizes translational research, aiming to develop effective anticancer therapies and biomaterials for bone and cartilage regeneration. As one of the leading interdisciplinary research teams at Uppsala University, we strive to bring innovative technologies from bench to bedside. In particular, our key interests lie in creating novel treatments for brain cancer and engineering 3D-printed bone-mimetic scaffolds, which have shown promising results in preclinical studies.

Group Members

Christos Leliopoulos
Hamidreza Mokhtari
Shima Tavakoli
Rohith Pavan Parvathaneni

Last updated: 2025-12-15

Content Responsible: victor kuismin(victor.kuismin@scilifelab.uu.se)