Oscar Fernandez-Capetillo

Karolinska Institutet

Keywords
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Key publications

1: Lecona E, Rodriguez-Acebes S, Specks J, Lopez-Contreras AJ, Ruppen I, Murga M, Muñoz J, Mendez J, Fernandez-Capetillo O. USP7 is a SUMO deubiquitinase essential for DNA replication. Nat Struct Mol Biol. 2016 Mar 7. doi: 10.1038/nsmb.3185.

2: Jacome A, Gutierrez-Martinez P, Schiavoni F, Tenaglia E, Martinez P, Rodríguez-Acebes S, Lecona E, Murga M, Méndez J, Blasco MA, Fernandez-Capetillo O. NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. EMBO J. 2015 Nov 3;34(21):2604-19.

3: Ruiz S, Lopez-Contreras AJ, Gabut M, Marion RM, Gutierrez-Martinez P, Bua S, Ramirez O, Olalde I, Rodrigo-Perez S, Li H, Marques-Bonet T, Serrano M, Blasco MA, Batada NN, Fernandez-Capetillo O. Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells. Nat Commun. 2015 Aug 21;6:8036.

4: Lopez-Contreras AJ, Specks J, Barlow JH, Ambrogio C, Desler C, Vikingsson S, Rodrigo-Perez S, Green H, Rasmussen LJ, Murga M, Nussenzweig A, Fernandez-Capetillo O. Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. Genes Dev. 2015 Apr 1;29(7):690-5.

5: Ruiz S, Fernandez-Capetillo O. The maternal side of Fanconi Anemia. Mol Cell. 2014 Sep 18;55(6):803-4.

SciLifeLab / Contact / Oscar Fernandez-Capetillo

Oscar Fernandez-Capetillo

Research Interests

DNA damage is a known cause of cancer and ageing. In this context, drugs that either generate DNA damage or inhibit DNA repair have shown good efficacy in the treatment of tumors, and are the current standard of care in several cases. Still, our knowledge of the specific synthetic lethal interactions that can enhance the efficacy of these treatments is somewhat rudimentary and there is room for improvement. I have previously been involved in the development of DNA repair inhibitors and help them arise clinical phases. At KI, I want to further pursue these translational activities by integrating our research with the national platforms available in the area of drug development. While our research will still have an angle towards DNA damage and repair, we will also explore other health-relevant areas such as the development of immune-modulators or new strategies to treat amyotrophic lateral sclerosis.

Group members

Oscar Fernandez-Capetillo, Professor
Per Moberg, Scientific Coordinator
Daniela Hühn, Project leader
Maria Häggblad, Research engineer
Louise Lidemalm, Laboratory technician
Bartlomiej Porebski, PostDoc
Xuexin Li, PhD Student
Myriam Barz, PhD Student
Oneka Perea, Research assistant
Hendrik Vogt, Research assistant

Alumni

Wareed Ahmed, postdoctoral researcher, 2020-2022
Alba Corman, PhD student, 2017-2022
Patrycia Michalska Dziama, postdoctoral researcher, 2020-2021
Pranauti Rajesh Panshikar, master student, 2020-2021
Valeria Colicchia, postdoctoral researcher, 2018-2021
Mimmi Olofsson, master student, 2021
Jordi Carreras-Puigvert, project leader and assistant professor, 2015-2020
Marlene Wolfsgruber, Bachelor student, 2020
Catherine Hansel, postdoctoral researcher, 2018-2020
Schayan Yousefian, master student, 2018-2019
Mirela Balan, postdoctoral researcher, 2018
Alba González, bachelor student Erasmus+, 2017-2018
Melania Zauri, postdoctoral researcher, 2017-2018
Pablo Marti Rodrigo, graduate research fellow, 2017-2018
Pournima Prabhakaran, master student, 2017
Kirsten Tschapalda, postdoctoral researcher, 2016-2017
Bomi Jung, postdoctoral researcher, 2016-2017
Jon Vallejo, visiting PhD student, 2016

Last updated: 2022-11-30

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